ABCC2 (ATP binding cassette subfamily C member 2)

2003-02-01  

Identity

HGNC
ABCC2
LOCATION
10q24.2
LOCUSID
1244
ALIAS
ABC30,CMOAT,DJS,MRP2,cMRP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1244
MIM: 601107
HGNC: 53
Ensembl: ENSG00000023839

Variants:

dbSNP: 1244
ClinVar: 1244
TCGA: ENSG00000023839
COSMIC: ABCC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000023839ENST00000647814Q92887
ENSG00000023839ENST00000648324A0A3B3IS94
ENSG00000023839ENST00000648523A0A3B3ITG8
ENSG00000023839ENST00000648689A0A3B3IRZ2
ENSG00000023839ENST00000649493A0A3B3IRU4
ENSG00000023839ENST00000649932A0A3B3IRZ2

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
ABC transportersKEGGko02010
ABC transportersKEGGhsa02010
Bile secretionKEGGko04976
Bile secretionKEGGhsa04976
Transmembrane transport of small moleculesREACTOMER-HSA-382551
ABC-family proteins mediated transportREACTOMER-HSA-382556
Platinum drug resistanceKEGGko01524
Platinum drug resistanceKEGGhsa01524
Antifolate resistanceKEGGko01523
Antifolate resistanceKEGGhsa01523

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10204tenofovirChemicalClinicalAnnotationassociatedPD17083032, 19400747, 25485598, 26287941, 26535588, 26807589, 31619748
PA10251atazanavirChemicalClinicalAnnotationassociatedPD26287941
PA10804imatinibChemicalClinicalAnnotationassociatedPD30237583
PA10810pemetrexedChemicalClinicalAnnotationassociatedPD
PA128406956fluorouracilChemicalClinicalAnnotationassociatedPD23314736
PA131285527oxaliplatinChemicalClinicalAnnotationassociatedPD23314736
PA132595336calceinChemicalClinicalAnnotation, VariantAnnotationassociatedPK22027652
PA133888799Organ TransplantationDiseaseClinicalAnnotationassociatedPK25163792
PA133950441hmg coa reductase inhibitorsChemicalPathwayassociated
PA134308647rosuvastatinChemicalVariantAnnotationassociatedPK30100615
PA142650384pitavastatinChemicalClinicalAnnotationassociatedPK23007012
PA143485705antiepilepticsChemicalClinicalAnnotation, Literature, MultilinkAnnotationassociatedPKPD21449672, 21799461, 22188362, 22256867, 22630058, 23697249, 24567120, 24624913, 25155934, 27816260
PA146123005talinololChemicalClinicalAnnotationassociated18334920
PA151958383Gastrointestinal Stromal TumorsDiseaseClinicalAnnotationassociatedPD30237583
PA164712708Drugs For Treatment Of TuberculosisChemicalClinicalAnnotationassociatedPD31648372
PA164713176Platinum compoundsChemicalPathwayassociated19525887
PA164748728mycophenolic acidChemicalClinicalAnnotationassociatedPK25163792, 28624888
PA164760843deferasiroxChemicalClinicalAnnotationassociatedPKPD25348619, 26403473
PA164925725Toxic liver diseaseDiseaseClinicalAnnotationassociatedPD31648372
PA165110775SN-38ChemicalPathwayassociated
PA165817016Kidney TransplantationDiseaseClinicalAnnotationassociatedPK25163792, 28316087, 28624888, 29318894
PA378NR1I2GenePathwayassociated21151855
PA443421Arrhythmias, CardiacDiseaseClinicalAnnotationassociatedPKPD16330681
PA443434Arthritis, RheumatoidDiseaseClinicalAnnotationassociatedPD18381794, 27217051
PA443560Breast NeoplasmsDiseaseClinicalAnnotationassociatedPKPD
PA443622Carcinoma, Non-Small-Cell LungDiseaseClinicalAnnotationassociatedPD18221820
PA443658Central Nervous System InfectionsDiseaseClinicalAnnotationassociatedPK29873816
PA443756Colonic NeoplasmsDiseaseClinicalAnnotationassociatedPD23314736
PA443937Drug ToxicityDiseaseClinicalAnnotationassociatedPKPD16330681
PA444065EpilepsyDiseaseClinicalAnnotationassociatedPKPD20216337, 21449672, 21799461, 22188362, 22256867, 22630058, 23252947, 23697249, 24567120, 25155934, 27816260
PA444109ExanthemaDiseaseClinicalAnnotationassociatedPD23237922
PA444516HypercholesterolemiaDiseaseClinicalAnnotationassociatedPD29178257
PA444682Kidney DiseasesDiseaseClinicalAnnotationassociatedPD17083032, 19400747, 25485598, 26535588, 26807589
PA444756Leukemia, LymphoidDiseaseClinicalAnnotationassociatedPK23069858, 24241962, 29791011
PA444845Lymphoma, Non-HodgkinDiseaseClinicalAnnotationassociatedPKPD16330681
PA444937MesotheliomaDiseaseClinicalAnnotationassociatedPD
PA445941TuberculosisDiseaseClinicalAnnotationassociatedPD31648372
PA446108Colorectal NeoplasmsDiseaseClinicalAnnotationassociatedPKPD18981587
PA446155Precursor Cell Lymphoblastic Leukemia-LymphomaDiseaseClinicalAnnotationassociatedPKPD24241962
PA446157Leukemia, B-Cell, AcuteDiseaseClinicalAnnotationassociatedPKPD23222202
PA446432beta-ThalassemiaDiseaseClinicalAnnotationassociatedPKPD25348619, 26403473
PA447230HIV InfectionsDiseaseClinicalAnnotationassociatedPKPD17083032, 19400747, 19842932, 22027652, 25485598, 26535588, 26774523, 26807589, 31619748
PA448500atorvastatinChemicalClinicalAnnotation, PathwayassociatedPD22186618, 29178257
PA448785carbamazepineChemicalClinicalAnnotation, PathwayassociatedPKPD20216337, 21449672, 21738081, 21799461, 22188362, 22256867, 22630058, 23252947, 23697249, 24567120, 25155934
PA448866ceftriaxoneChemicalClinicalAnnotationassociatedPK29873816
PA449014cisplatinChemicalClinicalAnnotationassociatedPD
PA449165cyclophosphamideChemicalClinicalAnnotationassociatedPD
PA449167cyclosporineChemicalClinicalAnnotationassociatedPK25163792, 28624888
PA449383docetaxelChemicalClinicalAnnotation, PathwayassociatedPKPD18294295, 21151855, 23188068
PA449412doxorubicinChemicalClinicalAnnotationassociatedPKPD16330681
PA449441efavirenzChemicalClinicalAnnotationassociatedPK26774523
PA449493erythromycinChemicalClinicalAnnotationassociatedPK
PA450085irinotecanChemicalClinicalAnnotation, PathwayassociatedPKPD18221820, 18981587
PA450163lamivudineChemicalPathwayassociated
PA450198leucovorinChemicalClinicalAnnotationassociatedPD23314736
PA450264lopinavirChemicalClinicalAnnotation, VariantAnnotationassociatedPKPD19842932, 22027652, 26287941
PA450272lovastatinChemicalPathwayassociated
PA450428methotrexateChemicalClinicalAnnotation, PathwayassociatedPKPD18381794, 21317831, 23069858, 23222202, 24241962, 25502615, 27217051, 29791011
PA450732oxcarbazepineChemicalClinicalAnnotationassociatedPKPD21449672, 21799461, 22188362, 22256867, 22630058, 23697249, 24567120, 25155934
PA450761paclitaxelChemicalPathwayassociated21151855
PA451089pravastatinChemicalClinicalAnnotation, PathwayassociatedPK17047488
PA451260ritonavirChemicalClinicalAnnotationassociatedPD26287941
PA451363simvastatinChemicalClinicalAnnotation, PathwayassociatedPD22186618
PA451578tacrolimusChemicalClinicalAnnotationassociatedPK28316087, 29318894
PA451581tamoxifenChemicalClinicalAnnotationassociatedPKPD
PA451879vincristineChemicalPathwayassociated
PA7000sorafenibChemicalClinicalAnnotationassociatedPD23237922

References

Pubmed IDYearTitleCitations
383167762024Transport mechanism of human bilirubin transporter ABCC2 tuned by the inter-module regulatory domain.2
383167762024Transport mechanism of human bilirubin transporter ABCC2 tuned by the inter-module regulatory domain.2
362538872023Impact of ABCC2 1249G>A and -24C>T Polymorphisms on Lacosamide Efficacy and Plasma Concentrations in Uygur Pediatric Patients With Epilepsy in China.1
362741062023Concurrence of novel mutations causing Gilbert's and Dubin-Johnson syndrome with poor clinical outcomes in a Han Chinese family.0
364635352023Effects of splicing-regulatory polymorphisms in ABCC2, ABCG2, and ABCB1 on methotrexate exposure in Chinese children with acute lymphoblastic leukemia.1
365075892023Genetic variations in ABC transporter genes as a predictive biomarker for toxicity in North Indian lung cancer patients undergoing platinum-based doublet chemotherapy.0
365377552023Association Between ABCG2, ABCB1, ABCC2 Efflux Transporter Single-Nucleotide Variants and Irinotecan Adverse Effects in Patients With Colorectal Cancer: A Real-Life Study.1
362538872023Impact of ABCC2 1249G>A and -24C>T Polymorphisms on Lacosamide Efficacy and Plasma Concentrations in Uygur Pediatric Patients With Epilepsy in China.1
362741062023Concurrence of novel mutations causing Gilbert's and Dubin-Johnson syndrome with poor clinical outcomes in a Han Chinese family.0
364635352023Effects of splicing-regulatory polymorphisms in ABCC2, ABCG2, and ABCB1 on methotrexate exposure in Chinese children with acute lymphoblastic leukemia.1
365075892023Genetic variations in ABC transporter genes as a predictive biomarker for toxicity in North Indian lung cancer patients undergoing platinum-based doublet chemotherapy.0
365377552023Association Between ABCG2, ABCB1, ABCC2 Efflux Transporter Single-Nucleotide Variants and Irinotecan Adverse Effects in Patients With Colorectal Cancer: A Real-Life Study.1
349588102022ABCC2 expression in papillary renal cell carcinoma provides better prognostic stratification than WHO/ISUP nucleolar grade.2
353254362022The ABCB1, ABCC2 and RALBP1 polymorphisms are associated with carbamazepine response in epileptic patient: a systematic review.1
354778522022In silico screening and analysis of single-nucleotide polymorphic variants of the ABCC2 gene affecting Dubin-Johnson syndrome.1

Citation

Dessen P

ABCC2 (ATP binding cassette subfamily C member 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/539/abcc2