H1-2 (H1.2 linker histone, cluster member)

2014-05-01  

Identity

HGNC
H1-2
LOCATION
6p22.2
LOCUSID
3006
ALIAS
H1.2,H1C,H1F2,H1s-1,HIST1H1C

Other Information

Locus ID:

NCBI: 3006
MIM: 142710
HGNC: 4716
Ensembl: ENSG00000187837

Variants:

dbSNP: 3006
ClinVar: 3006
TCGA: ENSG00000187837
COSMIC: H1-2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000187837ENST00000343677P16403

Pathways

PathwaySourceExternal ID
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Apoptotic execution phaseREACTOMER-HSA-75153
Apoptosis induced DNA fragmentationREACTOMER-HSA-140342
Activation of DNA fragmentation factorREACTOMER-HSA-211227
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
DNA Damage/Telomere Stress Induced SenescenceREACTOMER-HSA-2559586
Formation of Senescence-Associated Heterochromatin Foci (SAHF)REACTOMER-HSA-2559584

References

Pubmed IDYearTitleCitations
379947852024Interactome of intact chromatosome variants with site-specifically ubiquitylated and acetylated linker histone H1.2.0
383999502024Histone H1.2 Inhibited EMCV Replication through Enhancing MDA5-Mediated IFN-β Signaling Pathway.0
379947852024Interactome of intact chromatosome variants with site-specifically ubiquitylated and acetylated linker histone H1.2.0
383999502024Histone H1.2 Inhibited EMCV Replication through Enhancing MDA5-Mediated IFN-β Signaling Pathway.0
341084532021Site-specific ubiquitylation acts as a regulator of linker histone H1.13
341084532021Site-specific ubiquitylation acts as a regulator of linker histone H1.13
293019382018The linker histone H1.2 is a novel component of the nucleolar organizer regions.6
298445782018Destabilization of linker histone H1.2 is essential for ATM activation and DNA damage repair.38
303554472018The RNA interactome of human telomerase RNA reveals a coding-independent role for a histone mRNA in telomere homeostasis.10
293019382018The linker histone H1.2 is a novel component of the nucleolar organizer regions.6
298445782018Destabilization of linker histone H1.2 is essential for ATM activation and DNA damage repair.38
303554472018The RNA interactome of human telomerase RNA reveals a coding-independent role for a histone mRNA in telomere homeostasis.10
286147072017Linker Histone H1.2 Directs Genome-wide Chromatin Association of the Retinoblastoma Tumor Suppressor Protein and Facilitates Its Function.8
286147072017Linker Histone H1.2 Directs Genome-wide Chromatin Association of the Retinoblastoma Tumor Suppressor Protein and Facilitates Its Function.8
262096082016Quantitative Mass Spectrometry Reveals that Intact Histone H1 Phosphorylations are Variant Specific and Exhibit Single Molecule Hierarchical Dependence.20

Citation

Dessen P

H1-2 (H1.2 linker histone, cluster member)

Atlas Genet Cytogenet Oncol Haematol. 2014-05-01

Online version: http://atlasgeneticsoncology.org/gene/53900