GPR161 (G protein-coupled receptor 161)

2014-06-01  

Identity

HGNC
GPR161
LOCATION
1q24.2
LOCUSID
23432
ALIAS
RE2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23432
MIM: 612250
HGNC: 23694
Ensembl: ENSG00000143147

Variants:

dbSNP: 23432
ClinVar: 23432
TCGA: ENSG00000143147
COSMIC: GPR161

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143147ENST00000271357A0A0A0MQW8
ENSG00000143147ENST00000367835Q8N6U8
ENSG00000143147ENST00000367836Q8N6U8
ENSG00000143147ENST00000367838Q8N6U8
ENSG00000143147ENST00000537209Q8N6U8
ENSG00000143147ENST00000539777Q8N6U8
ENSG00000143147ENST00000546300Q8N6U8

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Hedgehog signaling pathwayKEGGko04340
Hedgehog signaling pathwayKEGGhsa04340
Signal TransductionREACTOMER-HSA-162582
Signaling by HedgehogREACTOMER-HSA-5358351
Hedgehog 'off' stateREACTOMER-HSA-5610787
Hedgehog 'on' stateREACTOMER-HSA-5632684

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
316096492020Germline GPR161 Mutations Predispose to Pediatric Medulloblastoma.34
316096492020Germline GPR161 Mutations Predispose to Pediatric Medulloblastoma.34
302569842019Dominant negative GPR161 rare variants are risk factors of human spina bifida.16
302569842019Dominant negative GPR161 rare variants are risk factors of human spina bifida.16
293861062018Basal Suppression of the Sonic Hedgehog Pathway by the G-Protein-Coupled Receptor Gpr161 Restricts Medulloblastoma Pathogenesis.29
293861062018Basal Suppression of the Sonic Hedgehog Pathway by the G-Protein-Coupled Receptor Gpr161 Restricts Medulloblastoma Pathogenesis.29
277319252017G-protein-coupled receptor signaling and neural tube closure defects.4
277319252017G-protein-coupled receptor signaling and neural tube closure defects.4
270021702016Smoothened determines β-arrestin-mediated removal of the G protein-coupled receptor Gpr161 from the primary cilium.81
273576762016Gpr161 anchoring of PKA consolidates GPCR and cAMP signaling.60
270021702016Smoothened determines β-arrestin-mediated removal of the G protein-coupled receptor Gpr161 from the primary cilium.81
273576762016Gpr161 anchoring of PKA consolidates GPCR and cAMP signaling.60
245995922014G-protein-coupled receptor GPR161 is overexpressed in breast cancer and is a promoter of cell proliferation and invasion.44
245995922014G-protein-coupled receptor GPR161 is overexpressed in breast cancer and is a promoter of cell proliferation and invasion.44
190646102009Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation.16

Citation

Dessen P

GPR161 (G protein-coupled receptor 161)

Atlas Genet Cytogenet Oncol Haematol. 2014-06-01

Online version: http://atlasgeneticsoncology.org/gene/53926