CHRM2 (cholinergic receptor muscarinic 2)

2014-06-01  

Identity

HGNC
CHRM2
LOCATION
7q33
LOCUSID
1129
ALIAS
HM2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1129
MIM: 118493
HGNC: 1951
Ensembl: ENSG00000181072

Variants:

dbSNP: 1129
ClinVar: 1129
TCGA: ENSG00000181072
COSMIC: CHRM2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000181072ENST00000320658P08172
ENSG00000181072ENST00000320658A4D1Q0
ENSG00000181072ENST00000401861P08172
ENSG00000181072ENST00000401861A4D1Q0
ENSG00000181072ENST00000445907P08172
ENSG00000181072ENST00000445907A4D1Q0
ENSG00000181072ENST00000453373P08172
ENSG00000181072ENST00000453373A4D1Q0

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Neuroactive ligand-receptor interactionKEGGko04080
Regulation of actin cytoskeletonKEGGko04810
Calcium signaling pathwayKEGGhsa04020
Neuroactive ligand-receptor interactionKEGGhsa04080
Regulation of actin cytoskeletonKEGGhsa04810
Cholinergic synapseKEGGhsa04725
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Amine ligand-binding receptorsREACTOMER-HSA-375280
Muscarinic acetylcholine receptorsREACTOMER-HSA-390648
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Cargo recognition for clathrin-mediated endocytosisREACTOMER-HSA-8856825

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA445876Tobacco Use DisorderDiseaseClinicalAnnotationassociatedPD19644963
PA450626nicotineChemicalClinicalAnnotationassociatedPD19644963

References

Pubmed IDYearTitleCitations
381853842024M2 muscarinic receptors negatively modulate cell migration in human glioblastoma cells.1
386838742024The C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria and regulates cell respiration under stress conditions.0
381853842024M2 muscarinic receptors negatively modulate cell migration in human glioblastoma cells.1
386838742024The C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria and regulates cell respiration under stress conditions.0
343598962021M2 Muscarinic Receptor Activation Impairs Mitotic Progression and Bipolar Mitotic Spindle Formation in Human Glioblastoma Cell Lines.5
343905682021Deep learning-based classification of breast cancer cells using transmembrane receptor dynamics.2
348155152021Vibrational spectroscopy analysis of ligand efficacy in human M(2) muscarinic acetylcholine receptor (M(2)R).3
343598962021M2 Muscarinic Receptor Activation Impairs Mitotic Progression and Bipolar Mitotic Spindle Formation in Human Glioblastoma Cell Lines.5
343905682021Deep learning-based classification of breast cancer cells using transmembrane receptor dynamics.2
348155152021Vibrational spectroscopy analysis of ligand efficacy in human M(2) muscarinic acetylcholine receptor (M(2)R).3
306237172020Pharmacogenetics of tardive dyskinesia in schizophrenia: The role of CHRM1 and CHRM2 muscarinic receptors.4
320802322020Modeling the allosteric modulation on a G-Protein Coupled Receptor: the case of M2 muscarinic Acetylcholine Receptor in complex with LY211960.1
321827592020Cross Interaction between M2 Muscarinic Receptor and Notch1/EGFR Pathway in Human Glioblastoma Cancer Stem Cells: Effects on Cell Cycle Progression and Survival.13
322343872020Group II muscarinic acetylcholine receptors attenuate hepatic injury via Nrf2/ARE pathway.2
306237172020Pharmacogenetics of tardive dyskinesia in schizophrenia: The role of CHRM1 and CHRM2 muscarinic receptors.4

Citation

Dessen P

CHRM2 (cholinergic receptor muscarinic 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-06-01

Online version: http://atlasgeneticsoncology.org/gene/53984/css/template-nav.css