ABCC3 (ATP binding cassette subfamily C member 3)

2003-08-01 Affiliation

Identity

HGNC

ABCC3

LOCATION

17q21.33

LOCUSID

8714

ALIAS

ABC31,EST90757,MLP2,MOAT-D,MRP3,cMOAT2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 8714
MIM: 604323
HGNC: 54
Ensembl: ENSG00000108846

Variants:

dbSNP: 8714
ClinVar: 8714
TCGA: ENSG00000108846
COSMIC: ABCC3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000108846	ENST00000285238	O15438
ENSG00000108846	ENST00000427699	O15438
ENSG00000108846	ENST00000502426	O15438
ENSG00000108846	ENST00000505699	O15438
ENSG00000108846	ENST00000510633	H0Y8T5
ENSG00000108846	ENST00000513511	D6RJE5
ENSG00000108846	ENST00000513745	H0Y8Q6
ENSG00000108846	ENST00000515585	H0Y9T4
ENSG00000108846	ENST00000515707	D6RAB7

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
ABC transporters	KEGG	ko02010
ABC transporters	KEGG	hsa02010
Bile secretion	KEGG	ko04976
Bile secretion	KEGG	hsa04976
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
ABC-family proteins mediated transport	REACTOME	R-HSA-382556
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Bile acid and bile salt metabolism	REACTOME	R-HSA-194068
Recycling of bile acids and salts	REACTOME	R-HSA-159418
Antifolate resistance	KEGG	ko01523
Antifolate resistance	KEGG	hsa01523

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA162263534	Ototoxicity	Disease	ClinicalAnnotation	associated		PD	25141953, 27457817, 31666714
PA166169457	tonsillectomy	Disease	VariantAnnotation	associated	PK
PA443937	Drug Toxicity	Disease	ClinicalAnnotation	associated		PD	25141953, 27457817, 31666714
PA445062	Neoplasms	Disease	ClinicalAnnotation	associated		PD	25141953, 27457817, 31666714
PA445208	Pain	Disease	ClinicalAnnotation	associated	PK		32090339
PA445522	Respiratory Insufficiency	Disease	VariantAnnotation	associated	PK
PA445601	Osteosarcoma	Disease	ClinicalAnnotation	associated		PD	22016816
PA445687	Sleep Apnea Syndromes	Disease	VariantAnnotation	associated	PK
PA446155	Precursor Cell Lymphoblastic Leukemia-Lymphoma	Disease	ClinicalAnnotation	associated	PK	PD	21606946
PA449014	cisplatin	Chemical	ClinicalAnnotation	associated		PD	22016816, 25141953, 27457817, 31666714
PA449165	cyclophosphamide	Chemical	ClinicalAnnotation	associated		PD	22016816
PA449412	doxorubicin	Chemical	ClinicalAnnotation	associated		PD	22016816
PA450163	lamivudine	Chemical	Pathway	associated
PA450428	methotrexate	Chemical	ClinicalAnnotation, Pathway	associated	PK	PD	21317831, 21606946, 22016816
PA450550	morphine	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PK		32090339
PA451879	vincristine	Chemical	ClinicalAnnotation, Pathway	associated		PD	22016816

References

Pubmed ID	Year	Title	Citations
38566304	2024	Downregulation of ABCC3 activates MAPK signaling through accumulation of deoxycholic acid in colorectal cancer cells.	1
38642845	2024	SMARCA4 (BRG1) activates ABCC3 transcription to promote hepatocellular carcinogenesis.	0
38566304	2024	Downregulation of ABCC3 activates MAPK signaling through accumulation of deoxycholic acid in colorectal cancer cells.	1
38642845	2024	SMARCA4 (BRG1) activates ABCC3 transcription to promote hepatocellular carcinogenesis.	0
35328066	2022	Association Study of SLCO1B3 and ABCC3 Genetic Variants in Gallstone Disease.	2
35328066	2022	Association Study of SLCO1B3 and ABCC3 Genetic Variants in Gallstone Disease.	2
33582321	2021	Effect of bile acids on the expression of MRP3 and MRP4: An In vitro study in HepG2 cell line.	5
33811842	2021	CircABCC3 knockdown inhibits glioblastoma cell malignancy by regulating miR-770-5p/SOX2 axis through PI3K/AKT signaling pathway.	8
35008510	2021	The Role of TRIP6, ABCC3 and CPS1 Expression in Resistance of Ovarian Cancer to Taxanes.	7
33582321	2021	Effect of bile acids on the expression of MRP3 and MRP4: An In vitro study in HepG2 cell line.	5
33811842	2021	CircABCC3 knockdown inhibits glioblastoma cell malignancy by regulating miR-770-5p/SOX2 axis through PI3K/AKT signaling pathway.	8
35008510	2021	The Role of TRIP6, ABCC3 and CPS1 Expression in Resistance of Ovarian Cancer to Taxanes.	7
32212330	2020	Prevalence of ABCC3-1767G/A polymorphism among patients with antiretroviral-associated hepatotoxicity.	3
32212330	2020	Prevalence of ABCC3-1767G/A polymorphism among patients with antiretroviral-associated hepatotoxicity.	3
29464551	2019	Immunohistochemical Assessment of the Expression of Biliary Transportation Proteins MRP2 and MRP3 in Hepatocellular Carcinoma and in Cholangiocarcinoma.	6

Citation

Dessen P

ABCC3 (ATP binding cassette subfamily C member 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/540/tumors-explorer/haematological-explorer/favicon/favicon-32x32.png