SARAF (store-operated calcium entry associated regulatory factor)

2014-06-01  

Identity

HGNC
SARAF
LOCATION
8p12
LOCUSID
51669
ALIAS
FOAP-7,HSPC035,TMEM66,XTP3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51669
MIM: 614768
HGNC: 28789
Ensembl: ENSG00000133872

Variants:

dbSNP: 51669
ClinVar: 51669
TCGA: ENSG00000133872
COSMIC: SARAF

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133872ENST00000256255Q96BY9
ENSG00000133872ENST00000256255A0A140VK59
ENSG00000133872ENST00000518174E5RK07
ENSG00000133872ENST00000518296H0YAN9
ENSG00000133872ENST00000518340E5RJV6
ENSG00000133872ENST00000520303E5RJV6
ENSG00000133872ENST00000521265H0YBH7
ENSG00000133872ENST00000522055E5RJG8
ENSG00000133872ENST00000522794E5RHW0
ENSG00000133872ENST00000523127H0YAZ1
ENSG00000133872ENST00000523761E5RFJ9
ENSG00000133872ENST00000545648Q96BY9

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
380730552024Reduced Ca(2+) mobilization in neonatal human platelets involves SARAF and pannexin-1.0
388020352024MiR-30a-5p isoform -1|1 promotes the progression of gastric cancer by inhibiting TMEM66 and reducing intratumoral cytotoxic T cells.0
380730552024Reduced Ca(2+) mobilization in neonatal human platelets involves SARAF and pannexin-1.0
388020352024MiR-30a-5p isoform -1|1 promotes the progression of gastric cancer by inhibiting TMEM66 and reducing intratumoral cytotoxic T cells.0
347050292021Bidirectional regulation of calcium release-activated calcium (CRAC) channel by SARAF.7
347050292021Bidirectional regulation of calcium release-activated calcium (CRAC) channel by SARAF.7
320795272020Chemoresistant ovarian cancer enhances its migration abilities by increasing store-operated Ca(2+) entry-mediated turnover of focal adhesions.21
323944842020Temporal modulation of calcium sensing in hematopoietic stem cells is crucial for proper stem cell expansion and engraftment.10
320795272020Chemoresistant ovarian cancer enhances its migration abilities by increasing store-operated Ca(2+) entry-mediated turnover of focal adhesions.21
323944842020Temporal modulation of calcium sensing in hematopoietic stem cells is crucial for proper stem cell expansion and engraftment.10
309759192019STIM1 phosphorylation at Y(316) modulates its interaction with SARAF and the activation of SOCE and I(CRAC).23
310824392019SARAF Luminal Domain Structure Reveals a Novel Domain-Swapped β-Sandwich Fold Important for SOCE Modulation.9
314933992019Ca(2+) Influx Channel Inhibitor SARAF Protects Mice From Acute Pancreatitis.19
309759192019STIM1 phosphorylation at Y(316) modulates its interaction with SARAF and the activation of SOCE and I(CRAC).23
310824392019SARAF Luminal Domain Structure Reveals a Novel Domain-Swapped β-Sandwich Fold Important for SOCE Modulation.9

Citation

Dessen P

SARAF (store-operated calcium entry associated regulatory factor)

Atlas Genet Cytogenet Oncol Haematol. 2014-06-01

Online version: http://atlasgeneticsoncology.org/gene/54028/favicon/js/web-card-_common.js