USO1 (USO1 vesicle transport factor)

2014-07-01  

Identity

HGNC
USO1
LOCATION
4q21.1
LOCUSID
8615
ALIAS
P115,TAP,VDP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8615
MIM: 603344
HGNC: 30904
Ensembl: ENSG00000138768

Variants:

dbSNP: 8615
ClinVar: 8615
TCGA: ENSG00000138768
COSMIC: USO1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138768ENST00000264904O60763
ENSG00000138768ENST00000514213O60763
ENSG00000138768ENST00000514213A0A024RDG1

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
COPII (Coat Protein 2) Mediated Vesicle TransportREACTOMER-HSA-204005
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic ProphaseREACTOMER-HSA-68875
Golgi Cisternae Pericentriolar Stack ReorganizationREACTOMER-HSA-162658
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
COPI-mediated anterograde transportREACTOMER-HSA-6807878

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
341629112021Focused CRISPR-Cas9 genetic screening reveals USO1 as a vulnerability in B-cell acute lymphoblastic leukemia.8
342931112021USO1 isoforms differentially promote liver cancer progression by dysregulating the ER-Golgi network.3
341629112021Focused CRISPR-Cas9 genetic screening reveals USO1 as a vulnerability in B-cell acute lymphoblastic leukemia.8
342931112021USO1 isoforms differentially promote liver cancer progression by dysregulating the ER-Golgi network.3
268984512016USO1 promotes tumor progression via activating Erk pathway in multiple myeloma cells.7
268984512016USO1 promotes tumor progression via activating Erk pathway in multiple myeloma cells.7
261845082015Lentivirus-mediated silencing of USO1 inhibits cell proliferation and migration of human colon cancer cells.6
261845082015Lentivirus-mediated silencing of USO1 inhibits cell proliferation and migration of human colon cancer cells.6
243795792013P115 promotes growth of gastric cancer through interaction with macrophage migration inhibitory factor.8
243795792013P115 promotes growth of gastric cancer through interaction with macrophage migration inhibitory factor.8
211477772011Tethering function of the caspase cleavage fragment of Golgi protein p115 promotes apoptosis via a p53-dependent pathway.12
215366792011The Golgi protein p115 associates with gamma-tubulin and plays a role in Golgi structure and mitosis progression.22
211477772011Tethering function of the caspase cleavage fragment of Golgi protein p115 promotes apoptosis via a p53-dependent pathway.12
215366792011The Golgi protein p115 associates with gamma-tubulin and plays a role in Golgi structure and mitosis progression.22
201265492010Armadillo motifs involved in vesicular transport.9

Citation

Dessen P

USO1 (USO1 vesicle transport factor)

Atlas Genet Cytogenet Oncol Haematol. 2014-07-01

Online version: http://atlasgeneticsoncology.org/gene/54044/deep-insight-explorer/case-report-explorer/