USO1 (USO1 vesicle transport factor)

2014-07-01  

Identity

HGNC
LOCATION
4q21.1
LOCUSID
ALIAS
P115,TAP,VDP
FUSION GENES

Other Information

Locus ID:

NCBI: 8615
MIM: 603344
HGNC: 30904
Ensembl: ENSG00000138768

Variants:

dbSNP: 8615
ClinVar: 8615
TCGA: ENSG00000138768
COSMIC: USO1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138768ENST00000264904O60763
ENSG00000138768ENST00000514213O60763
ENSG00000138768ENST00000514213A0A024RDG1

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
COPII (Coat Protein 2) Mediated Vesicle TransportREACTOMER-HSA-204005
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic ProphaseREACTOMER-HSA-68875
Golgi Cisternae Pericentriolar Stack ReorganizationREACTOMER-HSA-162658
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
COPI-mediated anterograde transportREACTOMER-HSA-6807878

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
341629112021Focused CRISPR-Cas9 genetic screening reveals USO1 as a vulnerability in B-cell acute lymphoblastic leukemia.8
342931112021USO1 isoforms differentially promote liver cancer progression by dysregulating the ER-Golgi network.3
341629112021Focused CRISPR-Cas9 genetic screening reveals USO1 as a vulnerability in B-cell acute lymphoblastic leukemia.8
342931112021USO1 isoforms differentially promote liver cancer progression by dysregulating the ER-Golgi network.3
268984512016USO1 promotes tumor progression via activating Erk pathway in multiple myeloma cells.7
268984512016USO1 promotes tumor progression via activating Erk pathway in multiple myeloma cells.7
261845082015Lentivirus-mediated silencing of USO1 inhibits cell proliferation and migration of human colon cancer cells.6
261845082015Lentivirus-mediated silencing of USO1 inhibits cell proliferation and migration of human colon cancer cells.6
243795792013P115 promotes growth of gastric cancer through interaction with macrophage migration inhibitory factor.8
243795792013P115 promotes growth of gastric cancer through interaction with macrophage migration inhibitory factor.8
211477772011Tethering function of the caspase cleavage fragment of Golgi protein p115 promotes apoptosis via a p53-dependent pathway.12
215366792011The Golgi protein p115 associates with gamma-tubulin and plays a role in Golgi structure and mitosis progression.22
211477772011Tethering function of the caspase cleavage fragment of Golgi protein p115 promotes apoptosis via a p53-dependent pathway.12
215366792011The Golgi protein p115 associates with gamma-tubulin and plays a role in Golgi structure and mitosis progression.22
201265492010Armadillo motifs involved in vesicular transport.9

Citation

Dessen P

USO1 (USO1 vesicle transport factor)

Atlas Genet Cytogenet Oncol Haematol. 2014-07-01

Online version: http://atlasgeneticsoncology.org/gene/54044/gene-explorer/favicon/apple-touch-icon.png