LHX2 (LIM homeobox 2)

2014-07-01  

Identity

HGNC
LHX2
LOCATION
9q33.3
LOCUSID
9355
ALIAS
LH2,hLhx2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9355
MIM: 603759
HGNC: 6594
Ensembl: ENSG00000106689

Variants:

dbSNP: 9355
ClinVar: 9355
TCGA: ENSG00000106689
COSMIC: LHX2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106689ENST00000373615P50458
ENSG00000106689ENST00000446480H7C0H1
ENSG00000106689ENST00000488674U3KQT5
ENSG00000106689ENST00000560961H0YM35

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
366492362023The LHX2-OTX2 transcriptional regulatory module controls retinal pigmented epithelium differentiation and underlies genetic risk for age-related macular degeneration.1
370576752023LHX2 haploinsufficiency causes a variable neurodevelopmental disorder.2
375183562023LIM Homeobox 2 Increases Adhesion-Regulating Molecule 1 Transcription to Facilitate the Pathological Progression of Oxidized Low-Density Lipoprotein-Stimulated Atherosclerotic Cell Models.0
366492362023The LHX2-OTX2 transcriptional regulatory module controls retinal pigmented epithelium differentiation and underlies genetic risk for age-related macular degeneration.1
370576752023LHX2 haploinsufficiency causes a variable neurodevelopmental disorder.2
375183562023LIM Homeobox 2 Increases Adhesion-Regulating Molecule 1 Transcription to Facilitate the Pathological Progression of Oxidized Low-Density Lipoprotein-Stimulated Atherosclerotic Cell Models.0
358641582022LHX2 facilitates the progression of nasopharyngeal carcinoma via activation of the FGF1/FGFR axis.2
358641582022LHX2 facilitates the progression of nasopharyngeal carcinoma via activation of the FGF1/FGFR axis.2
339333122021REGγ regulates hair cycle by activating Lgr5 positive hair follicle stem cells.2
339333122021REGγ regulates hair cycle by activating Lgr5 positive hair follicle stem cells.2
307657952019LIM homeobox 2 promotes interaction between human iPS-derived hepatic progenitors and iPS-derived hepatic stellate-like cells.10
317245362019LHX2 promotes malignancy and inhibits autophagy via mTOR in osteosarcoma and is negatively regulated by miR-129-5p.14
307657952019LIM homeobox 2 promotes interaction between human iPS-derived hepatic progenitors and iPS-derived hepatic stellate-like cells.10
317245362019LHX2 promotes malignancy and inhibits autophagy via mTOR in osteosarcoma and is negatively regulated by miR-129-5p.14
292787032018Overexpression of Lhx2 suppresses proliferation of human T cell acute lymphoblastic leukemia-derived cells, partly by reducing LMO2 protein levels.3

Citation

Dessen P

LHX2 (LIM homeobox 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-07-01

Online version: http://atlasgeneticsoncology.org/gene/54067