MARCHF6 (membrane associated ring-CH-type finger 6)

2014-08-01  

Identity

HGNC
MARCHF6
LOCATION
5p15.2
LOCUSID
10299
ALIAS
DOA10,FAME3,MARCH-VI,MARCH6,RNF176,TEB4

Other Information

Locus ID:

NCBI: 10299
MIM: 613297
HGNC: 30550
Ensembl: ENSG00000145495

Variants:

dbSNP: 10299
ClinVar: 10299
TCGA: ENSG00000145495
COSMIC: MARCHF6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145495ENST00000274140O60337
ENSG00000145495ENST00000449913O60337
ENSG00000145495ENST00000502795D6RHY7
ENSG00000145495ENST00000503788O60337
ENSG00000145495ENST00000510792A0A0B4J206
ENSG00000145495ENST00000640713D6RHY7

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
N-glycan trimming in the ER and Calnexin/Calreticulin cycleREACTOMER-HSA-532668
Calnexin/calreticulin cycleREACTOMER-HSA-901042
ER Quality Control Compartment (ERQC)REACTOMER-HSA-901032

References

Pubmed IDYearTitleCitations
330494052021The E3 ubiquitin ligase MARCHF6 as a metabolic integrator in cholesterol synthesis and beyond.9
342739542021MARCH6 promotes hepatocellular carcinoma development through up-regulation of ATF2.4
345121552021MARCH6 promotes Papillary Thyroid Cancer development by destabilizing DHX9.9
330494052021The E3 ubiquitin ligase MARCHF6 as a metabolic integrator in cholesterol synthesis and beyond.9
342739542021MARCH6 promotes hepatocellular carcinoma development through up-regulation of ATF2.4
345121552021MARCH6 promotes Papillary Thyroid Cancer development by destabilizing DHX9.9
319048142020The cholesterol synthesis enzyme lanosterol 14α-demethylase is post-translationally regulated by the E3 ubiquitin ligase MARCH6.11
327555702020The MARCH6-SQLE Axis Controls Endothelial Cholesterol Homeostasis and Angiogenic Sprouting.12
319048142020The cholesterol synthesis enzyme lanosterol 14α-demethylase is post-translationally regulated by the E3 ubiquitin ligase MARCH6.11
327555702020The MARCH6-SQLE Axis Controls Endothelial Cholesterol Homeostasis and Angiogenic Sprouting.12
305459372019Cholesterol increases protein levels of the E3 ligase MARCH6 and thereby stimulates protein degradation.14
306581892019Differential use of E2 ubiquitin conjugating enzymes for regulated degradation of the rate-limiting enzymes HMGCR and SQLE in cholesterol biosynthesis.9
314221152019Consulting prostate cancer cohort data uncovers transcriptional control: Regulation of the MARCH6 gene.6
316640392019Unstable TTTTA/TTTCA expansions in MARCH6 are associated with Familial Adult Myoclonic Epilepsy type 3.62
305459372019Cholesterol increases protein levels of the E3 ligase MARCH6 and thereby stimulates protein degradation.14

Citation

Dessen P

MARCHF6 (membrane associated ring-CH-type finger 6)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54088/js/lib/css/gene-fusions-explorer/