Identity
HGNC
LOCATION
13q32.1
LOCUSID
ALIAS
MOAT-B,MOATB,MRP4
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10257
MIM: 605250
HGNC: 55
Ensembl: ENSG00000125257
Variants:
dbSNP: 10257
ClinVar: 10257
TCGA: ENSG00000125257
COSMIC: ABCC4
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10005 | adefovir dipivoxil | Chemical | Pathway | associated | |||
| PA10204 | tenofovir | Chemical | ClinicalAnnotation, Pathway, VariantAnnotation | ambiguous | PK | PD | 17083032, 17597712, 18398970 |
| PA10227 | valganciclovir | Chemical | ClinicalAnnotation | associated | PD | 27402191 | |
| PA10804 | imatinib | Chemical | ClinicalAnnotation | associated | PD | 23127916 | |
| PA128406956 | fluorouracil | Chemical | ClinicalAnnotation | associated | PK | PD | 19696793 |
| PA151958383 | Gastrointestinal Stromal Tumors | Disease | ClinicalAnnotation | associated | PD | 23127916 | |
| PA164712563 | Bisphosphonates | Chemical | ClinicalAnnotation | associated | PD | ||
| PA164774763 | latanoprost | Chemical | ClinicalAnnotation | associated | PD | 25339146 | |
| PA165817016 | Kidney Transplantation | Disease | ClinicalAnnotation | associated | PD | 27402191 | |
| PA166163418 | rucaparib | Chemical | LabelAnnotation | associated | |||
| PA443560 | Breast Neoplasms | Disease | ClinicalAnnotation | associated | PK | PD | 19696793 |
| PA443842 | Death | Disease | VariantAnnotation | associated | PD | ||
| PA443937 | Drug Toxicity | Disease | ClinicalAnnotation | associated | PK | PD | 19696793 |
| PA444282 | Glaucoma, Open-Angle | Disease | ClinicalAnnotation | associated | PD | 25339146 | |
| PA444370 | Heart Failure | Disease | ClinicalAnnotation | associated | PD | 26927285 | |
| PA445062 | Neoplasms | Disease | ClinicalAnnotation | associated | PK | PD | 19696793 |
| PA445187 | Osteonecrosis | Disease | ClinicalAnnotation | associated | PD | ||
| PA446116 | Inflammatory Bowel Diseases | Disease | ClinicalAnnotation | associated | PK | PD | 20393862 |
| PA446155 | Precursor Cell Lymphoblastic Leukemia-Lymphoma | Disease | ClinicalAnnotation | associated | PD | 25348617 | |
| PA446157 | Leukemia, B-Cell, Acute | Disease | ClinicalAnnotation | associated | PK | PD | 23222202 |
| PA446661 | Carcinoma, Small Cell | Disease | ClinicalAnnotation | associated | PD | 23478653 | |
| PA447230 | HIV | Disease | ClinicalAnnotation, VariantAnnotation | ambiguous | PK | PD | 16791115, 17083032, 17597712, 18398970 |
| PA448515 | azathioprine | Chemical | ClinicalAnnotation | associated | PK | PD | 20393862 |
| PA449014 | cisplatin | Chemical | ClinicalAnnotation | associated | PD | 23478653 | |
| PA449165 | cyclophosphamide | Chemical | ClinicalAnnotation | associated | PK | PD | 19696793 |
| PA449177 | cytarabine | Chemical | MultilinkAnnotation | associated | 26842729 | ||
| PA449412 | doxorubicin | Chemical | ClinicalAnnotation | associated | PK | PD | 19696793 |
| PA449719 | furosemide | Chemical | ClinicalAnnotation | associated | PD | 26927285 | |
| PA450085 | irinotecan | Chemical | ClinicalAnnotation | associated | PD | 23478653 | |
| PA450163 | lamivudine | Chemical | Pathway | associated | |||
| PA450379 | mercaptopurine | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PK | PD | 20393862 |
| PA450428 | methotrexate | Chemical | ClinicalAnnotation, Pathway | associated | PK | PD | 23222202, 25348617, 25502615 |
| PA451954 | zidovudine | Chemical | ClinicalAnnotation, Pathway | associated | PK | 16791115, 22960662 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37988981 | 2024 | ABCC4 impacts megakaryopoiesis and protects megakaryocytes against 6-mercaptopurine induced cytotoxicity. | 0 |
| 37988981 | 2024 | ABCC4 impacts megakaryopoiesis and protects megakaryocytes against 6-mercaptopurine induced cytotoxicity. | 0 |
| 37563361 | 2023 | m6A-modified circABCC4 promotes stemness and metastasis of prostate cancer by recruiting IGF2BP2 to increase stability of CCAR1. | 4 |
| 37683641 | 2023 | Structural and mechanistic basis of substrate transport by the multidrug transporter MRP4. | 4 |
| 37563361 | 2023 | m6A-modified circABCC4 promotes stemness and metastasis of prostate cancer by recruiting IGF2BP2 to increase stability of CCAR1. | 4 |
| 37683641 | 2023 | Structural and mechanistic basis of substrate transport by the multidrug transporter MRP4. | 4 |
| 34693929 | 2022 | In-vitro characterization of coding variants with predicted functional implications in the efflux transporter multidrug resistance protein 4 (MRP4, ABCC4). | 1 |
| 34951141 | 2022 | Founder genetic variants of ABCC4 and ABCC11 in the Japanese population are not associated with the development of subacute myelo-optico-neuropathy (SMON). | 3 |
| 35226228 | 2022 | IL-10 contributes to gemcitabine resistance in extranodal NK/T-cell lymphoma cells via ABCC4. | 5 |
| 35269592 | 2022 | The Daily Expression of ABCC4 at the BCSFB Affects the Transport of Its Substrate Methotrexate. | 3 |
| 35295075 | 2022 | Specific inhibition of the transporter MRP4/ABCC4 affects multiple signaling pathways and thrombus formation in human platelets. | 2 |
| 35381563 | 2022 | Drug resistance biomarker ABCC4 of selinexor and immune feature in multiple myeloma. | 6 |
| 34693929 | 2022 | In-vitro characterization of coding variants with predicted functional implications in the efflux transporter multidrug resistance protein 4 (MRP4, ABCC4). | 1 |
| 34951141 | 2022 | Founder genetic variants of ABCC4 and ABCC11 in the Japanese population are not associated with the development of subacute myelo-optico-neuropathy (SMON). | 3 |
| 35226228 | 2022 | IL-10 contributes to gemcitabine resistance in extranodal NK/T-cell lymphoma cells via ABCC4. | 5 |
Citation
Dessen P
ABCC4 (ATP binding cassette subfamily C member 4)
Atlas Genet Cytogenet Oncol Haematol. 2003-11-01
Online version: http://atlasgeneticsoncology.org/gene/541/abcc4
