APOO (apolipoprotein O)

2014-08-01  

Identity

HGNC
APOO
LOCATION
Xp22.11
LOCUSID
79135
ALIAS
FAM121B,MIC26,MICOS26,Mic23,My025
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79135
MIM: 300753
HGNC: 28727
Ensembl: ENSG00000184831

Variants:

dbSNP: 79135
ClinVar: 79135
TCGA: ENSG00000184831
COSMIC: APOO

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000184831ENST00000379226Q9BUR5
ENSG00000184831ENST00000439528H7C1U8
ENSG00000184831ENST00000490078G3V1B6
ENSG00000184831ENST00000633372A0A0J9YXS4
ENSG00000184831ENST00000633432A0A0J9YXT7
ENSG00000184831ENST00000634086A0A0J9YWW6

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
376491612023A X-linked nonsense APOO/MIC26 variant causes a lethal mitochondrial disease with progeria-like phenotypes.0
376491612023A X-linked nonsense APOO/MIC26 variant causes a lethal mitochondrial disease with progeria-like phenotypes.0
355885782022Role of apolipoprotein O in autophagy via the p38 mitogen-activated protein kinase signaling pathway in myocardial infarction.1
355885782022Role of apolipoprotein O in autophagy via the p38 mitogen-activated protein kinase signaling pathway in myocardial infarction.1
324398082021Mutation in the MICOS subunit gene APOO (MIC26) associated with an X-linked recessive mitochondrial myopathy, lactic acidosis, cognitive impairment and autistic features.19
324398082021Mutation in the MICOS subunit gene APOO (MIC26) associated with an X-linked recessive mitochondrial myopathy, lactic acidosis, cognitive impairment and autistic features.19
327882262020MIC26 and MIC27 cooperate to regulate cardiolipin levels and the landscape of OXPHOS complexes.19
327882262020MIC26 and MIC27 cooperate to regulate cardiolipin levels and the landscape of OXPHOS complexes.19
300922692018Loss of MICOS complex integrity and mitochondrial damage, but not TDP-43 mitochondrial localisation, are likely associated with severity of CHCHD10-related diseases.29
300922692018Loss of MICOS complex integrity and mitochondrial damage, but not TDP-43 mitochondrial localisation, are likely associated with severity of CHCHD10-related diseases.29
257649792015The non-glycosylated isoform of MIC26 is a constituent of the mammalian MICOS complex and promotes formation of crista junctions.32
257649792015The non-glycosylated isoform of MIC26 is a constituent of the mammalian MICOS complex and promotes formation of crista junctions.32
247431512014Apolipoprotein O is mitochondrial and promotes lipotoxicity in heart.26
247431512014Apolipoprotein O is mitochondrial and promotes lipotoxicity in heart.26
243417432013Microarray analysis provides new insights into the function of apolipoprotein O in HepG2 cell line.6

Citation

Dessen P

APOO (apolipoprotein O)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54131