ASAH2 (N-acylsphingosine amidohydrolase 2)

2014-08-01  

Identity

HGNC
ASAH2
LOCATION
10q11.23
LOCUSID
56624
ALIAS
BCDase,HNAC1,LCDase,N-CDase,NCDase
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 56624
MIM: 611202
HGNC: 18860
Ensembl: ENSG00000188611

Variants:

dbSNP: 56624
ClinVar: 56624
TCGA: ENSG00000188611
COSMIC: ASAH2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000188611ENST00000329428A0A0C4DFQ8
ENSG00000188611ENST00000395526Q9NR71
ENSG00000188611ENST00000443575E9PBM9
ENSG00000188611ENST00000447815Q9NR71
ENSG00000188611ENST00000474434V9GY52
ENSG00000188611ENST00000489640V9GYJ5
ENSG00000188611ENST00000656090Q9NR71

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Sphingolipid metabolismKEGGko00600
Sphingolipid metabolismKEGGhsa00600
Metabolic pathwaysKEGGhsa01100
Sphingosine biosynthesisKEGGM00099
Sphingosine biosynthesisKEGGhsa_M00099
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Sphingolipid metabolismREACTOMER-HSA-428157
Glycosphingolipid metabolismREACTOMER-HSA-1660662

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
351343892022Measurement of neutral ceramidase activity in vitro and in vivo.1
351343892022Measurement of neutral ceramidase activity in vitro and in vivo.1
335471702021Asah2 Represses the p53-Hmox1 Axis to Protect Myeloid-Derived Suppressor Cells from Ferroptosis.36
335471702021Asah2 Represses the p53-Hmox1 Axis to Protect Myeloid-Derived Suppressor Cells from Ferroptosis.36
303893542019Neutral ceramidase: Advances in mechanisms, cell regulation, and roles in cancer.16
303893542019Neutral ceramidase: Advances in mechanisms, cell regulation, and roles in cancer.16
261905752015Structural Basis for Ceramide Recognition and Hydrolysis by Human Neutral Ceramidase.28
261905752015Structural Basis for Ceramide Recognition and Hydrolysis by Human Neutral Ceramidase.28
243979802014Adiponectin inhibits tumor necrosis factor-α-induced vascular inflammatory response via caveolin-mediated ceramidase recruitment and activation.42
243979802014Adiponectin inhibits tumor necrosis factor-α-induced vascular inflammatory response via caveolin-mediated ceramidase recruitment and activation.42
215304852011AP-1 binding transcriptionally regulates human neutral ceramidase.11
215312002011Transcriptional regulation of the human neutral ceramidase gene.3
215304852011AP-1 binding transcriptionally regulates human neutral ceramidase.11
215312002011Transcriptional regulation of the human neutral ceramidase gene.3
205206282010Hydrolytic pathway protects against ceramide-induced apoptosis in keratinocytes exposed to UVB.0

Citation

Dessen P

ASAH2 (N-acylsphingosine amidohydrolase 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54137