BIN2 (bridging integrator 2)

2014-08-01  

Identity

HGNC
BIN2
LOCATION
12q13.13
LOCUSID
51411
ALIAS
BRAP-1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51411
MIM: 605936
HGNC: 1053
Ensembl: ENSG00000110934

Variants:

dbSNP: 51411
ClinVar: 51411
TCGA: ENSG00000110934
COSMIC: BIN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110934ENST00000452142Q9UBW5
ENSG00000110934ENST00000544402Q9UBW5
ENSG00000110934ENST00000604560S4R418
ENSG00000110934ENST00000605423S4R3J0
ENSG00000110934ENST00000615107Q9UBW5

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
371183392021Inhibition of BIN2 extends reproductive lifespan.0
371183392021Inhibition of BIN2 extends reproductive lifespan.0
232850272012Bin2 is a membrane sculpting N-BAR protein that influences leucocyte podosomes, motility and phagocytosis.26
232850272012Bin2 is a membrane sculpting N-BAR protein that influences leucocyte podosomes, motility and phagocytosis.26
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
109038462000Bin2, a functionally nonredundant member of the BAR adaptor gene family.19
109038462000Bin2, a functionally nonredundant member of the BAR adaptor gene family.19

Citation

Dessen P

BIN2 (bridging integrator 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54157