CRLS1 (cardiolipin synthase 1)

2014-08-01  

Identity

HGNC
CRLS1
LOCATION
20p12.3
LOCUSID
54675
ALIAS
C20orf155,CLS,CLS1,GCD10,dJ967N21.6
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 54675
MIM: 608188
HGNC: 16148
Ensembl: ENSG00000088766

Variants:

dbSNP: 54675
ClinVar: 54675
TCGA: ENSG00000088766
COSMIC: CRLS1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000088766ENST00000378863Q9UJA2
ENSG00000088766ENST00000378868Q9UJA2
ENSG00000088766ENST00000452938Q6NTG3

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycerophospholipid metabolismKEGGko00564
Glycerophospholipid metabolismKEGGhsa00564
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
Glycerophospholipid biosynthesisREACTOMER-HSA-1483206
Acyl chain remodelling of PGREACTOMER-HSA-1482925
Synthesis of CLREACTOMER-HSA-1483076

References

Pubmed IDYearTitleCitations
351471732022Deleterious variants in CRLS1 lead to cardiolipin deficiency and cause an autosomal recessive multi-system mitochondrial disease.11
351471732022Deleterious variants in CRLS1 lead to cardiolipin deficiency and cause an autosomal recessive multi-system mitochondrial disease.11
340995972021LINC01272 Suppressed Cell Multiplication and Induced Apoptosis Via Regulating MiR-7-5p/CRLS1 Axis in Lung Cancer.7
340995972021LINC01272 Suppressed Cell Multiplication and Induced Apoptosis Via Regulating MiR-7-5p/CRLS1 Axis in Lung Cancer.7
308252072019Small regulatory polypeptide of amino acid response negatively relates to poor prognosis and controls hepatocellular carcinoma progression via regulating microRNA-5581-3p/human cardiolipin synthase 1.7
308252072019Small regulatory polypeptide of amino acid response negatively relates to poor prognosis and controls hepatocellular carcinoma progression via regulating microRNA-5581-3p/human cardiolipin synthase 1.7
292517712018Inactivation of cardiolipin synthase triggers changes in mitochondrial morphology.12
292517712018Inactivation of cardiolipin synthase triggers changes in mitochondrial morphology.12
225845712012Myocardial regulation of lipidomic flux by cardiolipin synthase: setting the beat for bioenergetic efficiency.22
225845712012Myocardial regulation of lipidomic flux by cardiolipin synthase: setting the beat for bioenergetic efficiency.22
206528262011Cardiolipin synthase-1 mRNA expression does not correlate with endogenous cardiolipin synthase enzyme activity in vitro and in vivo in mammalian lipopolysaccharide models of inflammation.2
206528262011Cardiolipin synthase-1 mRNA expression does not correlate with endogenous cardiolipin synthase enzyme activity in vitro and in vivo in mammalian lipopolysaccharide models of inflammation.2
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
190484142009Renal involvement in the antiphospholipid syndrome (APS)-APS nephropathy.25

Citation

Dessen P

CRLS1 (cardiolipin synthase 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54238/gene-fusions/meetings/favicon/gene-explorer/