DRD4 (dopamine receptor D4)

2014-08-01  

Identity

HGNC
DRD4
LOCATION
11p15.5
LOCUSID
1815
ALIAS
D4DR
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1815
MIM: 126452
HGNC: 3025
Ensembl: ENSG00000069696

Variants:

dbSNP: 1815
ClinVar: 1815
TCGA: ENSG00000069696
COSMIC: DRD4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000069696ENST00000176183P21917

Expression (GTEx)

0
1
2
3
4
5
6
7
8
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Amine ligand-binding receptorsREACTOMER-HSA-375280
Dopamine receptorsREACTOMER-HSA-390651
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

References

Pubmed IDYearTitleCitations
379889282024DRD4 VNTR 4/4 homozygosity as a genetic biomarker for treatment selection in patients with schizophrenia.1
383614072024Humanized dopamine D(4.7) receptor male mice display risk-taking behavior and deficits of social recognition and working memory in light/dark-dependent manner.0
379889282024DRD4 VNTR 4/4 homozygosity as a genetic biomarker for treatment selection in patients with schizophrenia.1
383614072024Humanized dopamine D(4.7) receptor male mice display risk-taking behavior and deficits of social recognition and working memory in light/dark-dependent manner.0
366353582023The effect of the 7R allele at the DRD4 locus on risk tolerance is independent of background risk in Senegalese fishermen.0
370735892023The impact of dopamine receptor D4, temperamental negativity, and household chaos on young twins' externalizing behaviors.0
370801732023Variation in the Dopamine-4-Receptor Gene in Patients with Type 1 Diabetes.0
378806582023Association of DRD2, DRD4 and COMT genes variants and their gene-gene interactions with antipsychotic treatment response in patients with schizophrenia.0
366353582023The effect of the 7R allele at the DRD4 locus on risk tolerance is independent of background risk in Senegalese fishermen.0
370735892023The impact of dopamine receptor D4, temperamental negativity, and household chaos on young twins' externalizing behaviors.0
370801732023Variation in the Dopamine-4-Receptor Gene in Patients with Type 1 Diabetes.0
378806582023Association of DRD2, DRD4 and COMT genes variants and their gene-gene interactions with antipsychotic treatment response in patients with schizophrenia.0
340090352022Machine Learning Prediction of ADHD Severity: Association and Linkage to ADGRL3, DRD4, and SNAP25.9
344066372022Different effects of the DRD4 genotype on intrinsic brain network connectivity strength in drug-naïve children with ADHD and healthy controls.3
347103322022Chronic pain and delinquency partially explain the effect of the DRD4 gene polymorphism on adult substance use.0

Citation

Dessen P

DRD4 (dopamine receptor D4)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54266