ELP3 (elongator acetyltransferase complex subunit 3)

2014-08-01  

Identity

HGNC
ELP3
LOCATION
8p21.1
LOCUSID
55140
ALIAS
KAT9
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55140
MIM: 612722
HGNC: 20696
Ensembl: ENSG00000134014

Variants:

dbSNP: 55140
ClinVar: 55140
TCGA: ENSG00000134014
COSMIC: ELP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134014ENST00000256398Q9H9T3
ENSG00000134014ENST00000380353Q9H9T3
ENSG00000134014ENST00000517975H0YC54
ENSG00000134014ENST00000518112E5RG26
ENSG00000134014ENST00000519261E5RIU1
ENSG00000134014ENST00000520270E5RIC0
ENSG00000134014ENST00000520288E5RIZ7
ENSG00000134014ENST00000521015Q9H9T3
ENSG00000134014ENST00000521099E5RHY2
ENSG00000134014ENST00000521570E5RHR2
ENSG00000134014ENST00000523357H0YAP7
ENSG00000134014ENST00000523687E5RG26
ENSG00000134014ENST00000524103B4DKA4
ENSG00000134014ENST00000537665Q9H9T3

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HATs acetylate histonesREACTOMER-HSA-3214847

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
376401142024Amyloid pathology reduces ELP3 expression and tRNA modifications leading to impaired proteostasis.1
376401142024Amyloid pathology reduces ELP3 expression and tRNA modifications leading to impaired proteostasis.1
357229992022Relation between the circular and linear form of the Elongator Acetyltransferase Complex Subunit 3 in the progression of triple-negative breast cancer.1
357229992022Relation between the circular and linear form of the Elongator Acetyltransferase Complex Subunit 3 in the progression of triple-negative breast cancer.1
313410092019ELP3 Acetyltransferase is phosphorylated and regulated by the oncogenic anaplastic lymphoma kinase (ALK).4
313410092019ELP3 Acetyltransferase is phosphorylated and regulated by the oncogenic anaplastic lymphoma kinase (ALK).4
298053032018Elongator promotes the migration and invasion of hepatocellular carcinoma cell by the phosphorylation of AKT.8
298053032018Elongator promotes the migration and invasion of hepatocellular carcinoma cell by the phosphorylation of AKT.8
278110572016Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer.86
278110572016Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer.86
247693942014Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress.130
251488702014Promoter hypermethylation may be an important mechanism of the transcriptional inactivation of ARRDC3, GATA5, and ELP3 in invasive ductal breast carcinoma.15
247693942014Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress.130
251488702014Promoter hypermethylation may be an important mechanism of the transcriptional inactivation of ARRDC3, GATA5, and ELP3 in invasive ductal breast carcinoma.15
208773002012Genome-wide association study of increasing suicidal ideation during antidepressant treatment in the GENDEP project.42

Citation

Dessen P

ELP3 (elongator acetyltransferase complex subunit 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54282/case-report-explorer/gene-fusions/img/logo-atlas-4.svg