FMNL3 (formin like 3)

2014-08-01  

Identity

HGNC
LOCATION
12q13.12
LOCUSID
ALIAS
FHOD3,FRL2,WBP-3,WBP3
FUSION GENES

Other Information

Locus ID:

NCBI: 91010
MIM: 616288
HGNC: 23698
Ensembl: ENSG00000161791

Variants:

dbSNP: 91010
ClinVar: 91010
TCGA: ENSG00000161791
COSMIC: FMNL3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000161791ENST00000335154Q8IVF7
ENSG00000161791ENST00000352151Q8IVF7
ENSG00000161791ENST00000550424F8VYL1
ENSG00000161791ENST00000550488F8W1F5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
349496582022Bioinformatic Prediction of Novel Signaling Pathways of Apoptosis-inducing Factor, Mitochondrion-associated 3 (AIFM3) and Their Roles in Metastasis of Cholangiocarcinoma Cells.2
354285192022Hsa_circ_0081534 facilitates malignant phenotypes by sequestering miR-874-3p and upregulating FMNL3 in nasopharyngeal carcinoma.0
349496582022Bioinformatic Prediction of Novel Signaling Pathways of Apoptosis-inducing Factor, Mitochondrion-associated 3 (AIFM3) and Their Roles in Metastasis of Cholangiocarcinoma Cells.2
354285192022Hsa_circ_0081534 facilitates malignant phenotypes by sequestering miR-874-3p and upregulating FMNL3 in nasopharyngeal carcinoma.0
309552182019High expression of FMNL3 associates with cancer cell migration, invasion, and unfavorable prognosis in tongue squamous cell carcinoma.8
317514252019A strategy to identify protein-N-myristoylation-dependent phosphorylation reactions of cellular proteins by using Phos-tag SDS-PAGE.4
309552182019High expression of FMNL3 associates with cancer cell migration, invasion, and unfavorable prognosis in tongue squamous cell carcinoma.8
317514252019A strategy to identify protein-N-myristoylation-dependent phosphorylation reactions of cellular proteins by using Phos-tag SDS-PAGE.4
302287822018Formin-like 3 regulates RhoC/FAK pathway and actin assembly to promote cell invasion in colorectal carcinoma.16
303738942018Roles for Ena/VASP proteins in FMNL3-mediated filopodial assembly.17
302287822018Formin-like 3 regulates RhoC/FAK pathway and actin assembly to promote cell invasion in colorectal carcinoma.16
303738942018Roles for Ena/VASP proteins in FMNL3-mediated filopodial assembly.17
276458942016MicroRNA-127 is a tumor suppressor in human esophageal squamous cell carcinoma through the regulation of oncogene FMNL3.15
276458942016MicroRNA-127 is a tumor suppressor in human esophageal squamous cell carcinoma through the regulation of oncogene FMNL3.15
254289842015The formin FMNL3 assembles plasma membrane protrusions that participate in cell-cell adhesion.20

Citation

Dessen P

FMNL3 (formin like 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54318/gene-fusions/css/css/lib/dataTables.bootstrap.min.css