GATAD2A (GATA zinc finger domain containing 2A)

2014-08-01  

Identity

HGNC
LOCATION
19p13.11
LOCUSID
ALIAS
p66alpha
FUSION GENES

Other Information

Locus ID:

NCBI: 54815
MIM: 614997
HGNC: 29989
Ensembl: ENSG00000167491

Variants:

dbSNP: 54815
ClinVar: 54815
TCGA: ENSG00000167491
COSMIC: GATAD2A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167491ENST00000358713Q86YP4
ENSG00000167491ENST00000358713A0A024R7K7
ENSG00000167491ENST00000360315Q86YP4
ENSG00000167491ENST00000360315A0A024R7K7
ENSG00000167491ENST00000404158Q86YP4
ENSG00000167491ENST00000404158A0A024R7M6
ENSG00000167491ENST00000417582C9JJK9
ENSG00000167491ENST00000418032H7C3H1
ENSG00000167491ENST00000429242C9JMI3
ENSG00000167491ENST00000432704C9JGN4
ENSG00000167491ENST00000444839C9JVY3
ENSG00000167491ENST00000457895C9JHD7
ENSG00000167491ENST00000494516V9GYX5
ENSG00000167491ENST00000609040V9GY85

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionREACTOMER-HSA-504046
RNA Polymerase I TranscriptionREACTOMER-HSA-73864
RNA Polymerase I Promoter ClearanceREACTOMER-HSA-73854
RNA Polymerase I Transcription InitiationREACTOMER-HSA-73762
Epigenetic regulation of gene expressionREACTOMER-HSA-212165
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HDACs deacetylate histonesREACTOMER-HSA-3214815
Positive epigenetic regulation of rRNA expressionREACTOMER-HSA-5250913
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through AcetylationREACTOMER-HSA-6804758
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expressionREACTOMER-HSA-427389

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
371813312023De novo variants in GATAD2A in individuals with a neurodevelopmental disorder: GATAD2A-related neurodevelopmental disorder.1
371813312023De novo variants in GATAD2A in individuals with a neurodevelopmental disorder: GATAD2A-related neurodevelopmental disorder.1
359041802022lncKRT16P6 promotes tongue squamous cell carcinoma progression by sponging miR‑3180 and regulating GATAD2A expression.3
359041802022lncKRT16P6 promotes tongue squamous cell carcinoma progression by sponging miR‑3180 and regulating GATAD2A expression.3
339632052021Germinal GLT8D1, GATAD2A and SLC25A39 mutations in a patient with a glomangiopericytal tumor and five different sarcomas over a 10-year period.1
339979552021GATA zinc finger domain-containing protein 2A (GATAD2A) deficiency reactivates fetal haemoglobin in patients with β-thalassaemia through impaired formation of methyl-binding domain protein 2 (MBD2)-containing nucleosome remodelling and deacetylation (NuRD) complex.4
349441032021p66α Suppresses Breast Cancer Cell Growth and Migration by Acting as Co-Activator of p53.2
339632052021Germinal GLT8D1, GATAD2A and SLC25A39 mutations in a patient with a glomangiopericytal tumor and five different sarcomas over a 10-year period.1
339979552021GATA zinc finger domain-containing protein 2A (GATAD2A) deficiency reactivates fetal haemoglobin in patients with β-thalassaemia through impaired formation of methyl-binding domain protein 2 (MBD2)-containing nucleosome remodelling and deacetylation (NuRD) complex.4
349441032021p66α Suppresses Breast Cancer Cell Growth and Migration by Acting as Co-Activator of p53.2
329342262020A shared genetic contribution to breast cancer and schizophrenia.19
329342262020A shared genetic contribution to breast cancer and schizophrenia.19
309558162019Circular RNA GATAD2A promotes H1N1 replication through inhibiting autophagy.37
313241982019Hsa_circ_0058124 promotes papillary thyroid cancer tumorigenesis and invasiveness through the NOTCH3/GATAD2A axis.70
309558162019Circular RNA GATAD2A promotes H1N1 replication through inhibiting autophagy.37

Citation

Dessen P

GATAD2A (GATA zinc finger domain containing 2A)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54325/gene-fusions-explorer/gene-fusions/js/web-card-_common.js