GATAD2A (GATA zinc finger domain containing 2A)

2014-08-01  

Identity

HGNC
GATAD2A
LOCATION
19p13.11
LOCUSID
54815
ALIAS
p66alpha
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 54815
MIM: 614997
HGNC: 29989
Ensembl: ENSG00000167491

Variants:

dbSNP: 54815
ClinVar: 54815
TCGA: ENSG00000167491
COSMIC: GATAD2A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167491ENST00000358713Q86YP4
ENSG00000167491ENST00000358713A0A024R7K7
ENSG00000167491ENST00000360315Q86YP4
ENSG00000167491ENST00000360315A0A024R7K7
ENSG00000167491ENST00000404158Q86YP4
ENSG00000167491ENST00000404158A0A024R7M6
ENSG00000167491ENST00000417582C9JJK9
ENSG00000167491ENST00000418032H7C3H1
ENSG00000167491ENST00000429242C9JMI3
ENSG00000167491ENST00000432704C9JGN4
ENSG00000167491ENST00000444839C9JVY3
ENSG00000167491ENST00000457895C9JHD7
ENSG00000167491ENST00000494516V9GYX5
ENSG00000167491ENST00000609040V9GY85

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionREACTOMER-HSA-504046
RNA Polymerase I TranscriptionREACTOMER-HSA-73864
RNA Polymerase I Promoter ClearanceREACTOMER-HSA-73854
RNA Polymerase I Transcription InitiationREACTOMER-HSA-73762
Epigenetic regulation of gene expressionREACTOMER-HSA-212165
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HDACs deacetylate histonesREACTOMER-HSA-3214815
Positive epigenetic regulation of rRNA expressionREACTOMER-HSA-5250913
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through AcetylationREACTOMER-HSA-6804758
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expressionREACTOMER-HSA-427389

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
371813312023De novo variants in GATAD2A in individuals with a neurodevelopmental disorder: GATAD2A-related neurodevelopmental disorder.1
371813312023De novo variants in GATAD2A in individuals with a neurodevelopmental disorder: GATAD2A-related neurodevelopmental disorder.1
359041802022lncKRT16P6 promotes tongue squamous cell carcinoma progression by sponging miR‑3180 and regulating GATAD2A expression.3
359041802022lncKRT16P6 promotes tongue squamous cell carcinoma progression by sponging miR‑3180 and regulating GATAD2A expression.3
339632052021Germinal GLT8D1, GATAD2A and SLC25A39 mutations in a patient with a glomangiopericytal tumor and five different sarcomas over a 10-year period.1
339979552021GATA zinc finger domain-containing protein 2A (GATAD2A) deficiency reactivates fetal haemoglobin in patients with β-thalassaemia through impaired formation of methyl-binding domain protein 2 (MBD2)-containing nucleosome remodelling and deacetylation (NuRD) complex.4
349441032021p66α Suppresses Breast Cancer Cell Growth and Migration by Acting as Co-Activator of p53.2
339632052021Germinal GLT8D1, GATAD2A and SLC25A39 mutations in a patient with a glomangiopericytal tumor and five different sarcomas over a 10-year period.1
339979552021GATA zinc finger domain-containing protein 2A (GATAD2A) deficiency reactivates fetal haemoglobin in patients with β-thalassaemia through impaired formation of methyl-binding domain protein 2 (MBD2)-containing nucleosome remodelling and deacetylation (NuRD) complex.4
349441032021p66α Suppresses Breast Cancer Cell Growth and Migration by Acting as Co-Activator of p53.2
329342262020A shared genetic contribution to breast cancer and schizophrenia.19
329342262020A shared genetic contribution to breast cancer and schizophrenia.19
309558162019Circular RNA GATAD2A promotes H1N1 replication through inhibiting autophagy.37
313241982019Hsa_circ_0058124 promotes papillary thyroid cancer tumorigenesis and invasiveness through the NOTCH3/GATAD2A axis.70
309558162019Circular RNA GATAD2A promotes H1N1 replication through inhibiting autophagy.37

Citation

Dessen P

GATAD2A (GATA zinc finger domain containing 2A)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54325/teaching-explorer/gene-fusions-explorer/js/template.js