GORASP2 (golgi reassembly stacking protein 2)

2014-08-01  

Identity

HGNC
GORASP2
LOCATION
2q31.1
LOCUSID
26003
ALIAS
GOLPH6,GRASP55,GRS2,p59
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 26003
MIM: 608693
HGNC: 17500
Ensembl: ENSG00000115806

Variants:

dbSNP: 26003
ClinVar: 26003
TCGA: ENSG00000115806
COSMIC: GORASP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115806ENST00000234160Q9H8Y8
ENSG00000115806ENST00000442798F8WF79
ENSG00000115806ENST00000444801F8WEG2
ENSG00000115806ENST00000454751F8WBR9
ENSG00000115806ENST00000455067F8WEH9

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic ProphaseREACTOMER-HSA-68875
Golgi Cisternae Pericentriolar Stack ReorganizationREACTOMER-HSA-162658

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
373732632023Golgi Reassembly Stacking Protein 2 Modulates Myometrial Contractility during Labor by Affecting ATP Production.0
373732632023Golgi Reassembly Stacking Protein 2 Modulates Myometrial Contractility during Labor by Affecting ATP Production.0
353128662022GRASP depletion-mediated Golgi fragmentation impairs glycosaminoglycan synthesis, sulfation, and secretion.12
353128662022GRASP depletion-mediated Golgi fragmentation impairs glycosaminoglycan synthesis, sulfation, and secretion.12
333015662021Rapid degradation of GRASP55 and GRASP65 reveals their immediate impact on the Golgi structure.23
342456712021An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress.24
345160012021GRASP55 regulates intra-Golgi localization of glycosylation enzymes to control glycosphingolipid biosynthesis.19
333015662021Rapid degradation of GRASP55 and GRASP65 reveals their immediate impact on the Golgi structure.23
342456712021An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress.24
345160012021GRASP55 regulates intra-Golgi localization of glycosylation enzymes to control glycosphingolipid biosynthesis.19
319158572020Nucleation-dependent amyloid fibrillation of human GRASP55 in aqueous solution.1
320676162020GRASP55: A Multifunctional Protein.3
319158572020Nucleation-dependent amyloid fibrillation of human GRASP55 in aqueous solution.1
320676162020GRASP55: A Multifunctional Protein.3
301878172019Identification of a novel GORASP2-ALK fusion in an ALK-positive large B-cell lymphoma.3

Citation

Dessen P

GORASP2 (golgi reassembly stacking protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54338/gene-fusions/js/lib/case-report-explorer/