HS3ST1 (heparan sulfate-glucosamine 3-sulfotransferase 1)

2014-08-01  

Identity

HGNC
HS3ST1
LOCATION
4p15.33
LOCUSID
9957
ALIAS
3OST,3OST1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9957
MIM: 603244
HGNC: 5194
Ensembl: ENSG00000002587

Variants:

dbSNP: 9957
ClinVar: 9957
TCGA: ENSG00000002587
COSMIC: HS3ST1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000002587ENST00000002596O14792
ENSG00000002587ENST00000002596A0A024R9R4
ENSG00000002587ENST00000510712E9PDE3
ENSG00000002587ENST00000514690E9PDE3

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycosaminoglycan biosynthesis - heparan sulfate / heparinKEGGko00534
Glycosaminoglycan biosynthesis - heparan sulfate / heparinKEGGhsa00534
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Heparan sulfate/heparin (HS-GAG) metabolismREACTOMER-HSA-1638091
HS-GAG biosynthesisREACTOMER-HSA-2022928

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
281265212017HS3ST1 genotype regulates antithrombin's inflammomodulatory tone and associates with atherosclerosis.13
281265212017HS3ST1 genotype regulates antithrombin's inflammomodulatory tone and associates with atherosclerosis.13
242472462013Bioengineered Chinese hamster ovary cells with Golgi-targeted 3-O-sulfotransferase-1 biosynthesize heparan sulfate with an antithrombin-binding site.13
242472462013Bioengineered Chinese hamster ovary cells with Golgi-targeted 3-O-sulfotransferase-1 biosynthesize heparan sulfate with an antithrombin-binding site.13
150960362004A conformational change in heparan sulfate 3-O-sulfotransferase-1 is induced by binding to heparan sulfate.6
150960362004A conformational change in heparan sulfate 3-O-sulfotransferase-1 is induced by binding to heparan sulfate.6

Citation

Dessen P

HS3ST1 (heparan sulfate-glucosamine 3-sulfotransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54369