IRX3 (iroquois homeobox 3)

2014-08-01  

Identity

HGNC
IRX3
LOCATION
16q12.2
LOCUSID
79191
ALIAS
IRX-1,IRXB1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79191
MIM: 612985
HGNC: 14360
Ensembl: ENSG00000177508

Variants:

dbSNP: 79191
ClinVar: 79191
TCGA: ENSG00000177508
COSMIC: IRX3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177508ENST00000329734P78415
ENSG00000177508ENST00000558054J3QR11

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
353286122022The Hematopoietic TALE-Code Shows Normal Activity of IRX1 in Myeloid Progenitors and Reveals Ectopic Expression of IRX3 and IRX5 in Acute Myeloid Leukemia.8
359578322022IRX3 plays an important role in the pathogenesis of metabolic-associated fatty liver disease by regulating hepatic lipid metabolism.4
364156962022Interaction analysis of FTO and IRX3 genes with obesity and related metabolic disorders in an admixed Latin American population: a possible risk increases of body weight excess.2
353286122022The Hematopoietic TALE-Code Shows Normal Activity of IRX1 in Myeloid Progenitors and Reveals Ectopic Expression of IRX3 and IRX5 in Acute Myeloid Leukemia.8
359578322022IRX3 plays an important role in the pathogenesis of metabolic-associated fatty liver disease by regulating hepatic lipid metabolism.4
364156962022Interaction analysis of FTO and IRX3 genes with obesity and related metabolic disorders in an admixed Latin American population: a possible risk increases of body weight excess.2
329241912021Clinical utility of irx3 in keratoconus.2
337769282021IRX3 Overexpression Enhances Ucp1 Expression In Vivo.3
340834882021Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of IRX3 and IRX5.46
329241912021Clinical utility of irx3 in keratoconus.2
337769282021IRX3 Overexpression Enhances Ucp1 Expression In Vivo.3
340834882021Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of IRX3 and IRX5.46
317515772020The homeobox factor Irx3 maintains adipogenic identity.7
320357362020Hypothalamic IRX3: A New Player in the Development of Obesity.15
326514042020Associations of nicotidamide-N-methyltransferase, FTO, and IRX3 genetic variants with body mass index and resting energy expenditure in Mexican subjects.7

Citation

Dessen P

IRX3 (iroquois homeobox 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54385/cancer-prone-explorer/favicon/manifest.json