LPAR5 (lysophosphatidic acid receptor 5)

2014-08-01  

Identity

HGNC
LPAR5
LOCATION
12p13.31
LOCUSID
57121
ALIAS
GPR92,GPR93,KPG_010,LPA5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 57121
MIM: 606926
HGNC: 13307
Ensembl: ENSG00000184574

Variants:

dbSNP: 57121
ClinVar: 57121
TCGA: ENSG00000184574
COSMIC: LPAR5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000184574ENST00000329858Q9H1C0
ENSG00000184574ENST00000329858Q5KU18
ENSG00000184574ENST00000431922Q9H1C0
ENSG00000184574ENST00000431922Q5KU18

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Pathways in cancerKEGGhsa05200
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Lysosphingolipid and LPA receptorsREACTOMER-HSA-419408
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
370378312023Potential role of LPAR5 gene in prognosis and immunity of thyroid papillary carcinoma and pan-cancer.1
370612032023Emerging roles of lysophosphatidic acid receptor subtype 5 (LPAR5) in inflammatory diseases and cancer.6
371870932023Crosstalk between cannabinoid receptor 2 and lysophosphatidic acid receptor 5.1
370378312023Potential role of LPAR5 gene in prognosis and immunity of thyroid papillary carcinoma and pan-cancer.1
370612032023Emerging roles of lysophosphatidic acid receptor subtype 5 (LPAR5) in inflammatory diseases and cancer.6
371870932023Crosstalk between cannabinoid receptor 2 and lysophosphatidic acid receptor 5.1
361990692022LPAR5 confers radioresistance to cancer cells associated with EMT activation via the ERK/Snail pathway.7
365912202022Infiltration of LPAR5(+) macrophages in osteosarcoma tumor microenvironment predicts better outcomes.1
361990692022LPAR5 confers radioresistance to cancer cells associated with EMT activation via the ERK/Snail pathway.7
365912202022Infiltration of LPAR5(+) macrophages in osteosarcoma tumor microenvironment predicts better outcomes.1
334522322021Lysophosphatidic acid mediates the pathogenesis of psoriasis by activating keratinocytes through LPAR5.7
335404912021LPAR5 promotes thyroid carcinoma cell proliferation and migration by activating class IA PI3K catalytic subunit p110β.10
339750302021Control of Intestinal Epithelial Permeability by Lysophosphatidic Acid Receptor 5.6
346625222021Interference with lysophosphatidic acid receptor 5 ameliorates oxidized low-density lipoprotein-induced human umbilical vein endothelial cell injury by inactivating NOD-like receptor family, pyrin domain containing 3 inflammasome signaling.5
334522322021Lysophosphatidic acid mediates the pathogenesis of psoriasis by activating keratinocytes through LPAR5.7

Citation

Dessen P

LPAR5 (lysophosphatidic acid receptor 5)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54426