MGST2 (microsomal glutathione S-transferase 2)

2014-08-01  

Identity

HGNC
MGST2
LOCATION
4q31.1
LOCUSID
4258
ALIAS
GST2,MGST-II
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4258
MIM: 601733
HGNC: 7063
Ensembl: ENSG00000085871

Variants:

dbSNP: 4258
ClinVar: 4258
TCGA: ENSG00000085871
COSMIC: MGST2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000085871ENST00000265498Q99735
ENSG00000085871ENST00000503816Q99735
ENSG00000085871ENST00000506797Q99735
ENSG00000085871ENST00000616265Q99735

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glutathione metabolismKEGGko00480
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Drug metabolism - cytochrome P450KEGGko00982
Glutathione metabolismKEGGhsa00480
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Drug metabolism - cytochrome P450KEGGhsa00982
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
Glutathione conjugationREACTOMER-HSA-156590
Aflatoxin activation and detoxificationREACTOMER-HSA-5423646
Platinum drug resistanceKEGGko01524
Platinum drug resistanceKEGGhsa01524
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
337419272021Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis.9
337419272021Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis.9
260666102015Trimeric microsomal glutathione transferase 2 displays one third of the sites reactivity.9
260666102015Trimeric microsomal glutathione transferase 2 displays one third of the sites reactivity.9
234098382013Catalytic characterization of human microsomal glutathione S-transferase 2: identification of rate-limiting steps.17
234098382013Catalytic characterization of human microsomal glutathione S-transferase 2: identification of rate-limiting steps.17
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
193430462009Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.4
193430462009Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.4
164983982006A novel MGST2 non-synonymous mutation in a Chinese pedigree with psoriasis vulgaris.0
167733122006Systematic evaluation of association between the microsomal glutathione S-transferase 2 common variation and psoriasis vulgaris in Chinese population.2
167733122006Systematic evaluation of association between the microsomal glutathione S-transferase 2 common variation and psoriasis vulgaris in Chinese population.2
164983982006A novel MGST2 non-synonymous mutation in a Chinese pedigree with psoriasis vulgaris.0
167733122006Systematic evaluation of association between the microsomal glutathione S-transferase 2 common variation and psoriasis vulgaris in Chinese population.2

Citation

Dessen P

MGST2 (microsomal glutathione S-transferase 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54455/css/lib/favicon/deep-insight-explorer/