MTCL1 (microtubule crosslinking factor 1)

2014-08-01  

Identity

HGNC
MTCL1
LOCATION
18p11.22
LOCUSID
23255
ALIAS
CCDC165,KIAA0802,SOGA2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23255
MIM: 615766
HGNC: 29121
Ensembl: ENSG00000168502

Variants:

dbSNP: 23255
ClinVar: 23255
TCGA: ENSG00000168502
COSMIC: MTCL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168502ENST00000306329Q9Y4B5
ENSG00000168502ENST00000359865Q9Y4B5
ENSG00000168502ENST00000400050Q9Y4B5
ENSG00000168502ENST00000517570Q9Y4B5
ENSG00000168502ENST00000518815Q9Y4B5
ENSG00000168502ENST00000520495J3QL92
ENSG00000168502ENST00000523122J3QLE1

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381271072023Circular RNA MTCL1 targets SMAD3 by sponging miR-145-5p for regulation of cell proliferation and migration in Hirschsprung's disease.1
381271072023Circular RNA MTCL1 targets SMAD3 by sponging miR-145-5p for regulation of cell proliferation and migration in Hirschsprung's disease.1
335872252021SOGA1 and SOGA2/MTCL1 are CLASP-interacting proteins required for faithful chromosome segregation in human cells.1
335872252021SOGA1 and SOGA2/MTCL1 are CLASP-interacting proteins required for faithful chromosome segregation in human cells.1
305482552019A study in a Polish ataxia cohort indicates genetic heterogeneity and points to MTCL1 as a novel candidate gene.4
305482552019A study in a Polish ataxia cohort indicates genetic heterogeneity and points to MTCL1 as a novel candidate gene.4
287870322017Molecular basis of the microtubule-regulating activity of microtubule crosslinking factor 1.2
287870322017Molecular basis of the microtubule-regulating activity of microtubule crosslinking factor 1.2
275215662016A regulatory subunit of protein phosphatase 2A, PPP2R5E, regulates the abundance of microtubule crosslinking factor 1.4
275215662016A regulatory subunit of protein phosphatase 2A, PPP2R5E, regulates the abundance of microtubule crosslinking factor 1.4
253666632014MTCL1 crosslinks and stabilizes non-centrosomal microtubules on the Golgi membrane.16
253666632014MTCL1 crosslinks and stabilizes non-centrosomal microtubules on the Golgi membrane.16
186493582008Replication of a genome-wide case-control study of esophageal squamous cell carcinoma.9
186493582008Replication of a genome-wide case-control study of esophageal squamous cell carcinoma.9

Citation

Dessen P

MTCL1 (microtubule crosslinking factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54475