NSUN4 (NOP2/Sun RNA methyltransferase 4)

2014-08-01  

Identity

HGNC
NSUN4
LOCATION
1p33
LOCUSID
387338
ALIAS
SHTAP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 387338
MIM: 615394
HGNC: 31802
Ensembl: ENSG00000117481

Variants:

dbSNP: 387338
ClinVar: 387338
TCGA: ENSG00000117481
COSMIC: NSUN4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000117481ENST00000307089M0R1K5
ENSG00000117481ENST00000469918A0A087WUV3
ENSG00000117481ENST00000474844Q96CB9
ENSG00000117481ENST00000486270A0A087X0V6
ENSG00000117481ENST00000495427A0A087WT36
ENSG00000117481ENST00000498008Q6ZRQ1
ENSG00000117481ENST00000537428Q96CB9

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
rRNA processingREACTOMER-HSA-72312
rRNA processing in the mitochondrionREACTOMER-HSA-8868766
rRNA modification in the mitochondrionREACTOMER-HSA-6793080

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
347440732022m5C RNA methyltransferase-related gene NSUN4 stimulates malignant progression of hepatocellular carcinoma and can be a prognostic marker.11
347440732022m5C RNA methyltransferase-related gene NSUN4 stimulates malignant progression of hepatocellular carcinoma and can be a prognostic marker.11
243879842014Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain.140
243879842014Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain.140
229496732012Structure of the human MTERF4-NSUN4 protein complex that regulates mitochondrial ribosome biogenesis.59
229496732012Structure of the human MTERF4-NSUN4 protein complex that regulates mitochondrial ribosome biogenesis.59
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.39
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.39

Citation

Dessen P

NSUN4 (NOP2/Sun RNA methyltransferase 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54510