PAN3 (poly(A) specific ribonuclease subunit PAN3)

2014-08-01  

Identity

HGNC
PAN3
LOCATION
13q12.2
LOCUSID
255967
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 255967
MIM: 617448
HGNC: 29991
Ensembl: ENSG00000152520

Variants:

dbSNP: 255967
ClinVar: 255967
TCGA: ENSG00000152520
COSMIC: PAN3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152520ENST00000380958Q58A45
ENSG00000152520ENST00000399613A0A0C4DFZ9

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
Gene ExpressionREACTOMER-HSA-74160
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
Deadenylation of mRNAREACTOMER-HSA-429947

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
314014082019CircPAN3 contributes to drug resistance in acute myeloid leukemia through regulation of autophagy.51
314014082019CircPAN3 contributes to drug resistance in acute myeloid leukemia through regulation of autophagy.51
285594912017Antagonistic actions of two human Pan3 isoforms on global mRNA turnover.7
285594912017Antagonistic actions of two human Pan3 isoforms on global mRNA turnover.7
254460912014Arsenite inhibits mRNA deadenylation through proteolytic degradation of Tob and Pan3.4
254460912014Arsenite inhibits mRNA deadenylation through proteolytic degradation of Tob and Pan3.4
145836022004Identification of a human cytoplasmic poly(A) nuclease complex stimulated by poly(A)-binding protein.53
145836022004Identification of a human cytoplasmic poly(A) nuclease complex stimulated by poly(A)-binding protein.53

Citation

Dessen P

PAN3 (poly(A) specific ribonuclease subunit PAN3)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54525