PARD6G (par-6 family cell polarity regulator gamma)

2014-08-01  

Identity

HGNC
PARD6G
LOCATION
18q23
LOCUSID
84552
ALIAS
PAR-6G,PAR6gamma
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84552
MIM: 608976
HGNC: 16076
Ensembl: ENSG00000178184

Variants:

dbSNP: 84552
ClinVar: 84552
TCGA: ENSG00000178184
COSMIC: PARD6G

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000178184ENST00000353265Q9BYG4
ENSG00000178184ENST00000463384K7ELH1
ENSG00000178184ENST00000470488Q9BYG4

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Tight junctionKEGGko04530
Axon guidanceKEGGhsa04360
Tight junctionKEGGhsa04530
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Cell-Cell communicationREACTOMER-HSA-1500931
Cell junction organizationREACTOMER-HSA-446728
Cell-cell junction organizationREACTOMER-HSA-421270
Tight junction interactionsREACTOMER-HSA-420029

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
260730862016Par6G suppresses cell proliferation and is targeted by loss-of-function mutations in multiple cancers.11
260730862016Par6G suppresses cell proliferation and is targeted by loss-of-function mutations in multiple cancers.11
232647372013Par6γ is at the mother centriole and controls centrosomal protein composition through a Par6α-dependent pathway.10
232647372013Par6γ is at the mother centriole and controls centrosomal protein composition through a Par6α-dependent pathway.10
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78

Citation

Dessen P

PARD6G (par-6 family cell polarity regulator gamma)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54529