RUSC2 (RUN and SH3 domain containing 2)

2014-08-01  

Identity

HGNC
LOCATION
9p13.3
LOCUSID
ALIAS
Iporin,MRT61
FUSION GENES

Other Information

Locus ID:

NCBI: 9853
MIM: 611053
HGNC: 23625
Ensembl: ENSG00000198853

Variants:

dbSNP: 9853
ClinVar: 9853
TCGA: ENSG00000198853
COSMIC: RUSC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198853ENST00000361226Q8N2Y8
ENSG00000198853ENST00000455600Q8N2Y8

Expression (GTEx)

0
50
100
150

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
344324922021RUSC2 and WDR47 oppositely regulate kinesin-1-dependent distribution of ATG9A to the cell periphery.9
344324922021RUSC2 and WDR47 oppositely regulate kinesin-1-dependent distribution of ATG9A to the cell periphery.9
319324782020EHD1 and RUSC2 Control Basal Epidermal Growth Factor Receptor Cell Surface Expression and Recycling.6
327442432020Crystal structure of the FYCO1 RUN domain suggests possible interfaces with small GTPases.3
319324782020EHD1 and RUSC2 Control Basal Epidermal Growth Factor Receptor Cell Surface Expression and Recycling.6
327442432020Crystal structure of the FYCO1 RUN domain suggests possible interfaces with small GTPases.3
309056722019Rab35/ACAP2 and Rab35/RUSC2 Complex Structures Reveal Molecular Basis for Effector Recognition by Rab35 GTPase.8
311998892019Circ_RUSC2 upregulates the expression of miR-661 target gene SYK and regulates the function of vascular smooth muscle cells.19
309056722019Rab35/ACAP2 and Rab35/RUSC2 Complex Structures Reveal Molecular Basis for Effector Recognition by Rab35 GTPase.8
311998892019Circ_RUSC2 upregulates the expression of miR-661 target gene SYK and regulates the function of vascular smooth muscle cells.19
302628842018AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A.72
302628842018AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A.72
272385702016EGF-stimulated activation of Rab35 regulates RUSC2-GIT2 complex formation to stabilize GIT2 during directional lung cancer cell migration.19
276121862016Loss-of-function mutation in RUSC2 causes intellectual disability and secondary microcephaly.7
272385702016EGF-stimulated activation of Rab35 regulates RUSC2-GIT2 complex formation to stabilize GIT2 during directional lung cancer cell migration.19

Citation

Dessen P

RUSC2 (RUN and SH3 domain containing 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54597/js/gene-fusions-explorer/img/logo-atlas-4.svg