SLC30A7 (solute carrier family 30 member 7)

2014-08-01  

Identity

HGNC
SLC30A7
LOCATION
1p21.2
LOCUSID
148867
ALIAS
ZNT7,ZnT-7,ZnTL2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 148867
MIM: 611149
HGNC: 19306
Ensembl: ENSG00000162695

Variants:

dbSNP: 148867
ClinVar: 148867
TCGA: ENSG00000162695
COSMIC: SLC30A7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162695ENST00000357650Q8NEW0
ENSG00000162695ENST00000370111H0Y362
ENSG00000162695ENST00000370112Q8NEW0

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Insulin processingREACTOMER-HSA-264876
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Metal ion SLC transportersREACTOMER-HSA-425410
Zinc transportersREACTOMER-HSA-435354
Zinc efflux and compartmentalization by the SLC30 familyREACTOMER-HSA-435368

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383936932024Investigation of cuproptosis regulator-mediated modification patterns and SLC30A7 function in GBM.0
383936932024Investigation of cuproptosis regulator-mediated modification patterns and SLC30A7 function in GBM.0
368216392023Identification of novel compound heterozygous variants in the SLC30A7 (ZNT7) gene in two French brothers with stunted growth, testicular hypoplasia and bone marrow failure.2
368216392023Identification of novel compound heterozygous variants in the SLC30A7 (ZNT7) gene in two French brothers with stunted growth, testicular hypoplasia and bone marrow failure.2
356072882022MiR-200c-3p regulates pyroptosis by targeting SLC30A7 in diabetic retinopathy.0
357514292022De novo heterozygous variants in SLC30A7 are a candidate cause for Joubert syndrome.2
356072882022MiR-200c-3p regulates pyroptosis by targeting SLC30A7 in diabetic retinopathy.0
357514292022De novo heterozygous variants in SLC30A7 are a candidate cause for Joubert syndrome.2
336495342021ZnT7 RNAi favors Raf(GOF)scrib(-/-)-induced tumor growth and invasion in Drosophila through JNK signaling pathway.7
336495342021ZnT7 RNAi favors Raf(GOF)scrib(-/-)-induced tumor growth and invasion in Drosophila through JNK signaling pathway.7
285583002017Urine cadmium levels and albuminuria in a general population from Spain: A gene-environment interaction analysis.22
285583002017Urine cadmium levels and albuminuria in a general population from Spain: A gene-environment interaction analysis.22
232750322013Zinc transporter 5 and zinc transporter 7 induced by high glucose protects peritoneal mesothelial cells from undergoing apoptosis.8
232750322013Zinc transporter 5 and zinc transporter 7 induced by high glucose protects peritoneal mesothelial cells from undergoing apoptosis.8
214621062010Gastrointestinal factors influencing zinc absorption and homeostasis.42

Citation

Dessen P

SLC30A7 (solute carrier family 30 member 7)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54636/css/lib/gene-fusions-explorer/