SORCS1 (sortilin related VPS10 domain containing receptor 1)

2014-08-01  

Identity

HGNC
SORCS1
LOCATION
10q25.1
LOCUSID
114815
ALIAS
hSorCS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 114815
MIM: 606283
HGNC: 16697
Ensembl: ENSG00000108018

Variants:

dbSNP: 114815
ClinVar: 114815
TCGA: ENSG00000108018
COSMIC: SORCS1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108018ENST00000263054Q8WY21
ENSG00000108018ENST00000344440A0A0A0MRC2
ENSG00000108018ENST00000369698X6R7D6
ENSG00000108018ENST00000452214H7C2U3
ENSG00000108018ENST00000612154A0A087WTQ9
ENSG00000108018ENST00000622431A0A087WTI0

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
366972542023SorCS1 inhibits amyloid-β binding to neurexin and rescues amyloid-β-induced synaptic pathology.5
366972542023SorCS1 inhibits amyloid-β binding to neurexin and rescues amyloid-β-induced synaptic pathology.5
318290242020Decreased expression of SorCS1 in colorectal cancer: An independent predictor of poor prognosis.1
318290242020Decreased expression of SorCS1 in colorectal cancer: An independent predictor of poor prognosis.1
288271482017Hidden Twins: SorCS Neuroreceptors Form Stable Dimers.10
288271482017Hidden Twins: SorCS Neuroreceptors Form Stable Dimers.10
270524932016SORCS1 polymorphism and insulin secretion in obese women with polycystic ovary syndrome.2
270524932016SORCS1 polymorphism and insulin secretion in obese women with polycystic ovary syndrome.2
241283062014Human sorCS1 binds sortilin and hampers its cellular functions.8
241283062014Human sorCS1 binds sortilin and hampers its cellular functions.8
237004272013The genetic variation of SORCS1 is associated with late-onset Alzheimer's disease in Chinese Han population.13
237808482013SORCS1 contributes to the development of renal disease in rats and humans.11
237004272013The genetic variation of SORCS1 is associated with late-onset Alzheimer's disease in Chinese Han population.13
237808482013SORCS1 contributes to the development of renal disease in rats and humans.11
223537532012SORCS1 and APOE polymorphisms interact to confer risk for late-onset Alzheimer's disease in a Northern Han Chinese population.0

Citation

Dessen P

SORCS1 (sortilin related VPS10 domain containing receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54655/gene-explorer/css/lib/haematological-explorer/