TBCB (tubulin folding cofactor B)

2014-08-01  

Identity

HGNC
TBCB
LOCATION
19q13.12
LOCUSID
1155
ALIAS
CG22,CKAP1,CKAPI
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1155
MIM: 601303
HGNC: 1989
Ensembl: ENSG00000105254

Variants:

dbSNP: 1155
ClinVar: 1155
TCGA: ENSG00000105254
COSMIC: TBCB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105254ENST00000221855Q99426
ENSG00000105254ENST00000585746Q99426
ENSG00000105254ENST00000586868K7ER04
ENSG00000105254ENST00000588385K7EP07
ENSG00000105254ENST00000589624K7EQH0
ENSG00000105254ENST00000589996K7EK42
ENSG00000105254ENST00000591296K7EL99
ENSG00000105254ENST00000629269K7EQH0
ENSG00000105254ENST00000651435A0A494C0X0

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Post-chaperonin tubulin folding pathwayREACTOMER-HSA-389977

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
300305932018Dysregulation of a novel miR-1825/TBCB/TUBA4A pathway in sporadic and familial ALS.24
300305932018Dysregulation of a novel miR-1825/TBCB/TUBA4A pathway in sporadic and familial ALS.24
283938582017HILI destabilizes microtubules by suppressing phosphorylation and Gigaxonin-mediated degradation of TBCB.6
283938582017HILI destabilizes microtubules by suppressing phosphorylation and Gigaxonin-mediated degradation of TBCB.6
255052422015Microtubule-associated proteins 1 (MAP1) promote human immunodeficiency virus type I (HIV-1) intracytoplasmic routing to the nucleus.43
259088462015The structure of the complex between α-tubulin, TBCE and TBCB reveals a tubulin dimer dissociation mechanism.20
255052422015Microtubule-associated proteins 1 (MAP1) promote human immunodeficiency virus type I (HIV-1) intracytoplasmic routing to the nucleus.43
259088462015The structure of the complex between α-tubulin, TBCE and TBCB reveals a tubulin dimer dissociation mechanism.20
229409192013Autoinhibition of TBCB regulates EB1-mediated microtubule dynamics.8
229409192013Autoinhibition of TBCB regulates EB1-mediated microtubule dynamics.8
227777412012Tubulin-binding cofactor B is a direct interaction partner of the dynactin subunit p150(Glued).3
227777412012Tubulin-binding cofactor B is a direct interaction partner of the dynactin subunit p150(Glued).3
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
190382512009Tubulin cofactor B regulates microtubule densities during microglia transition to the reactive states.12

Citation

Dessen P

TBCB (tubulin folding cofactor B)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54692/case-report-explorer/favicon/css/lib/dataTables.bootstrap.min.css