UGP2 (UDP-glucose pyrophosphorylase 2)

2014-08-01 Affiliation

Identity

HGNC

UGP2

LOCATION

2p15

LOCUSID

7360

ALIAS

DEE83,EIEE83,SVUGP2,UDPG,UDPGP,UDPGP2,UGP1,UGPP1,UGPP2,pHC379

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7360
MIM: 191760
HGNC: 12527
Ensembl: ENSG00000169764

Variants:

dbSNP: 7360
ClinVar: 7360
TCGA: ENSG00000169764
COSMIC: UGP2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000169764	ENST00000337130	Q16851
ENSG00000169764	ENST00000394417	Q16851
ENSG00000169764	ENST00000394417	A0A140VKE1
ENSG00000169764	ENST00000445915	E7EUC7
ENSG00000169764	ENST00000466642	F8WC70
ENSG00000169764	ENST00000467400	F2Z3H1
ENSG00000169764	ENST00000467648	Q16851
ENSG00000169764	ENST00000467648	A0A140VKE1
ENSG00000169764	ENST00000467999	H7C500
ENSG00000169764	ENST00000472047	C9JWG0
ENSG00000169764	ENST00000475462	C9JVG3
ENSG00000169764	ENST00000480679	C9J3M0
ENSG00000169764	ENST00000482668	C9JTZ5
ENSG00000169764	ENST00000483108	F2Z3P4
ENSG00000169764	ENST00000484142	C9J6Q0
ENSG00000169764	ENST00000487042	F8WC70
ENSG00000169764	ENST00000487640	F8WC70
ENSG00000169764	ENST00000488245	C9JUW1
ENSG00000169764	ENST00000491621	C9JNZ1
ENSG00000169764	ENST00000493222	F2Z3P4
ENSG00000169764	ENST00000496334	F8WDA2
ENSG00000169764	ENST00000497510	F2Z3H1
ENSG00000169764	ENST00000497883	C9JQU9
ENSG00000169764	ENST00000613823	A0A087WYS1
ENSG00000169764	ENST00000626380	F8WC70
ENSG00000169764	ENST00000627474	F2Z3P4
ENSG00000169764	ENST00000640075	F2Z3H1

Expression (GTEx)

100

150

200

250

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Pentose and glucuronate interconversions	KEGG	ko00040
Galactose metabolism	KEGG	ko00052
Starch and sucrose metabolism	KEGG	ko00500
Amino sugar and nucleotide sugar metabolism	KEGG	ko00520
Pentose and glucuronate interconversions	KEGG	hsa00040
Galactose metabolism	KEGG	hsa00052
Starch and sucrose metabolism	KEGG	hsa00500
Amino sugar and nucleotide sugar metabolism	KEGG	hsa00520
Metabolic pathways	KEGG	hsa01100
Nucleotide sugar biosynthesis, eukaryotes	KEGG	hsa_M00361
Nucleotide sugar biosynthesis, eukaryotes	KEGG	M00361
Nucleotide sugar biosynthesis, glucose => UDP-glucose	KEGG	hsa_M00549
Nucleotide sugar biosynthesis, glucose => UDP-glucose	KEGG	M00549
Metabolism	REACTOME	R-HSA-1430728
Metabolism of carbohydrates	REACTOME	R-HSA-71387
Glucose metabolism	REACTOME	R-HSA-70326
Glycogen synthesis	REACTOME	R-HSA-3322077
Biological oxidations	REACTOME	R-HSA-211859
Phase II conjugation	REACTOME	R-HSA-156580
Glucuronidation	REACTOME	R-HSA-156588
Formation of the active cofactor, UDP-glucuronate	REACTOME	R-HSA-173599

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
34330832	2021	UDP-glucose pyrophosphorylase 2, a regulator of glycogen synthesis and glycosylation, is critical for pancreatic cancer growth.	12
34330832	2021	UDP-glucose pyrophosphorylase 2, a regulator of glycogen synthesis and glycosylation, is critical for pancreatic cancer growth.	12
31820119	2020	Loss of UGP2 in brain leads to a severe epileptic encephalopathy, emphasizing that bi-allelic isoform-specific start-loss mutations of essential genes can cause genetic diseases.	29
32188137	2020	Defects in Galactose Metabolism and Glycoconjugate Biosynthesis in a UDP-Glucose Pyrophosphorylase-Deficient Cell Line Are Reversed by Adding Galactose to the Growth Medium.	4
32733617	2020	Low UGP2 Expression Is Associated with Tumour Progression and Predicts Poor Prognosis in Hepatocellular Carcinoma.	10
31820119	2020	Loss of UGP2 in brain leads to a severe epileptic encephalopathy, emphasizing that bi-allelic isoform-specific start-loss mutations of essential genes can cause genetic diseases.	29
32188137	2020	Defects in Galactose Metabolism and Glycoconjugate Biosynthesis in a UDP-Glucose Pyrophosphorylase-Deficient Cell Line Are Reversed by Adding Galactose to the Growth Medium.	4
32733617	2020	Low UGP2 Expression Is Associated with Tumour Progression and Predicts Poor Prognosis in Hepatocellular Carcinoma.	10
30816613	2019	Identification of UGP2 as a progression marker that promotes cell growth and motility in human glioma.	15
30816613	2019	Identification of UGP2 as a progression marker that promotes cell growth and motility in human glioma.	15
29347944	2018	Expression of UGP2 and CFL1 expression levels in benign and malignant pancreatic lesions and their clinicopathological significance.	17
29347944	2018	Expression of UGP2 and CFL1 expression levels in benign and malignant pancreatic lesions and their clinicopathological significance.	17
23254995	2013	Octamerization is essential for enzymatic function of human UDP-glucose pyrophosphorylase.	15
23254995	2013	Octamerization is essential for enzymatic function of human UDP-glucose pyrophosphorylase.	15
22132858	2012	The crystal structure of human UDP-glucose pyrophosphorylase reveals a latch effect that influences enzymatic activity.	11

Citation

Dessen P

UGP2 (UDP-glucose pyrophosphorylase 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54750