WIPF2 (WAS/WASL interacting protein family member 2)

2014-08-01  

Identity

HGNC
LOCATION
17q21.2
LOCUSID
ALIAS
WICH,WIRE
FUSION GENES

Other Information

Locus ID:

NCBI: 147179
MIM: 609692
HGNC: 30923
Ensembl: ENSG00000171475

Variants:

dbSNP: 147179
ClinVar: 147179
TCGA: ENSG00000171475
COSMIC: WIPF2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171475ENST00000323571Q8TF74
ENSG00000171475ENST00000394103A8MWR2
ENSG00000171475ENST00000582781J3QQS0
ENSG00000171475ENST00000583130Q8TF74
ENSG00000171475ENST00000583268J3KSA3
ENSG00000171475ENST00000584296J3QKM5
ENSG00000171475ENST00000585043Q8TF74

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
Regulation of actin dynamics for phagocytic cup formationREACTOMER-HSA-2029482
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate WASPs and WAVEsREACTOMER-HSA-5663213

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
312991652020RP5-1120P11.3 promotes hepatocellular carcinoma development via the miR-196b-5p-WIPF2 axis.4
312991652020RP5-1120P11.3 promotes hepatocellular carcinoma development via the miR-196b-5p-WIPF2 axis.4
307929692019Phagocytosis of Aspergillus fumigatus by Human Bronchial Epithelial Cells Is Mediated by the Arp2/3 Complex and WIPF2.9
314145112019WIPF2 promotes Shigella flexneri actin-based motility and cell-to-cell spread.0
307929692019Phagocytosis of Aspergillus fumigatus by Human Bronchial Epithelial Cells Is Mediated by the Arp2/3 Complex and WIPF2.9
314145112019WIPF2 promotes Shigella flexneri actin-based motility and cell-to-cell spread.0
270093652016WIP and WICH/WIRE co-ordinately control invadopodium formation and maturation in human breast cancer cell invasion.11
270093652016WIP and WICH/WIRE co-ordinately control invadopodium formation and maturation in human breast cancer cell invasion.11
255052422015Microtubule-associated proteins 1 (MAP1) promote human immunodeficiency virus type I (HIV-1) intracytoplasmic routing to the nucleus.43
255052422015Microtubule-associated proteins 1 (MAP1) promote human immunodeficiency virus type I (HIV-1) intracytoplasmic routing to the nucleus.43
232959552013High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migration and invasion.57
232959552013High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migration and invasion.57
122132102002The WASP-binding protein WIRE has a role in the regulation of the actin filament system downstream of the platelet-derived growth factor receptor.11
122132102002The WASP-binding protein WIRE has a role in the regulation of the actin filament system downstream of the platelet-derived growth factor receptor.11

Citation

Dessen P

WIPF2 (WAS/WASL interacting protein family member 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54783/case-report-explorer/favicon/js/web-card-_common.js