WIPI2 (WD repeat domain, phosphoinositide interacting 2)

2014-08-01  

Identity

HGNC
WIPI2
LOCATION
7p22.1
LOCUSID
26100
ALIAS
ATG18B,Atg21,CGI-50,IDDSSA,WIPI-2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 26100
MIM: 609225
HGNC: 32225
Ensembl: ENSG00000157954

Variants:

dbSNP: 26100
ClinVar: 26100
TCGA: ENSG00000157954
COSMIC: WIPI2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000157954ENST00000288828Q9Y4P8
ENSG00000157954ENST00000288828A0A024R823
ENSG00000157954ENST00000382384Q9Y4P8
ENSG00000157954ENST00000401525Q9Y4P8
ENSG00000157954ENST00000404704Q9Y4P8
ENSG00000157954ENST00000484262Q9Y4P8

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
Autophagy - otherKEGGko04136
Autophagy - otherKEGGhsa04136

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
368729142023STING directly recruits WIPI2 for autophagosome formation during STING-induced autophagy.14
368729142023STING directly recruits WIPI2 for autophagosome formation during STING-induced autophagy.14
345055722021Structural basis for membrane recruitment of ATG16L1 by WIPI2 in autophagy.22
345055722021Structural basis for membrane recruitment of ATG16L1 by WIPI2 in autophagy.22
323238452020WIPI2 depletion inhibits the growth of hepatocellular carcinoma cells through the AMPK signaling pathway.8
324374992020A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy.46
323238452020WIPI2 depletion inhibits the growth of hepatocellular carcinoma cells through the AMPK signaling pathway.8
324374992020A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy.46
309681112019A mutation in the major autophagy gene, WIPI2, associated with global developmental abnormalities.21
309681112019A mutation in the major autophagy gene, WIPI2, associated with global developmental abnormalities.21
291335252018Optineurin promotes autophagosome formation by recruiting the autophagy-related Atg12-5-16L1 complex to phagophores containing the Wipi2 protein.33
303400222018mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux.56
291335252018Optineurin promotes autophagosome formation by recruiting the autophagy-related Atg12-5-16L1 complex to phagophores containing the Wipi2 protein.33
303400222018mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux.56
287606512017Evaluation of urinary autophagy transcripts expression in diabetic kidney disease.7

Citation

Dessen P

WIPI2 (WD repeat domain, phosphoinositide interacting 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54784