IL17B (interleukin 17B)

2014-08-01  

Identity

HGNC
IL17B
LOCATION
5q32
LOCUSID
27190
ALIAS
IL-17B,IL-20,NIRF,ZCYTO7

Other Information

Locus ID:

NCBI: 27190
MIM: 604627
HGNC: 5982
Ensembl: ENSG00000127743

Variants:

dbSNP: 27190
ClinVar: 27190
TCGA: ENSG00000127743
COSMIC: IL17B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127743ENST00000261796Q9UHF5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
380331682023Variants of IL6, IL10, FCN2, RNASE3, IL12B and IL17B loci are associated with Schistosoma mansoni worm burden in the Albert Nile region of Uganda.0
380331682023Variants of IL6, IL10, FCN2, RNASE3, IL12B and IL17B loci are associated with Schistosoma mansoni worm burden in the Albert Nile region of Uganda.0
355704062022Potential role of INTERLEUKIN-17 in the pathogenesis of oral lichen planus: a systematic review with META-analysis.6
355704062022Potential role of INTERLEUKIN-17 in the pathogenesis of oral lichen planus: a systematic review with META-analysis.6
307704172019Cutting Edge: IL-17B Uses IL-17RA and IL-17RB to Induce Type 2 Inflammation from Human Lymphocytes.18
307704172019Cutting Edge: IL-17B Uses IL-17RA and IL-17RB to Induce Type 2 Inflammation from Human Lymphocytes.18
294965382018A positive feedback loop of IL-17B-IL-17RB activates ERK/β-catenin to promote lung cancer metastasis.19
294965382018A positive feedback loop of IL-17B-IL-17RB activates ERK/β-catenin to promote lung cancer metastasis.19
277031472017Variants in SKP1, PROB1, and IL17B genes at keratoconus 5q31.1-q35.3 susceptibility locus identified by whole-exome sequencing.9
281458812017IL-17B activated mesenchymal stem cells enhance proliferation and migration of gastric cancer cells.14
281607542017The role of IL17B-IL17RB signaling pathway in breast cancer.29
277031472017Variants in SKP1, PROB1, and IL17B genes at keratoconus 5q31.1-q35.3 susceptibility locus identified by whole-exome sequencing.9
281458812017IL-17B activated mesenchymal stem cells enhance proliferation and migration of gastric cancer cells.14
281607542017The role of IL17B-IL17RB signaling pathway in breast cancer.29
271468812016Non-tumor tissue derived interleukin-17B activates IL-17RB/AKT/β-catenin pathway to enhance the stemness of gastric cancer.22

Citation

Dessen P

IL17B (interleukin 17B)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54833/favicon/gene-fusions-explorer/