IFNLR1 (interferon lambda receptor 1)

2014-09-01  

Identity

HGNC
IFNLR1
LOCATION
1p36.11
LOCUSID
163702
ALIAS
CRF2/12,IFNLR,IL-28R1,IL28RA,LICR2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 163702
MIM: 607404
HGNC: 18584
Ensembl: ENSG00000185436

Variants:

dbSNP: 163702
ClinVar: 163702
TCGA: ENSG00000185436
COSMIC: IFNLR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185436ENST00000327535Q8IU57
ENSG00000185436ENST00000327575Q8IU57
ENSG00000185436ENST00000374418Q8IU57
ENSG00000185436ENST00000374419Q5VTX9
ENSG00000185436ENST00000374421Q8IU57

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
380708302024Interferon lambda receptor-1 isoforms differentially influence gene expression and HBV replication in stem cell-derived hepatocytes.0
380708302024Interferon lambda receptor-1 isoforms differentially influence gene expression and HBV replication in stem cell-derived hepatocytes.0
369923412023Influence of Canonical and Non-Canonical IFNLR1 Isoform Expression on Interferon Lambda Signaling.2
369923412023Influence of Canonical and Non-Canonical IFNLR1 Isoform Expression on Interferon Lambda Signaling.2
332695312021Interferon III-related IL28RA variant is associated with rheumatoid arthritis and systemic lupus erythematosus and specific disease sub-phenotypes.1
337513442021Association of TNFRSF1A and IFNLR1 Gene Polymorphisms with the Risk of Developing Breast Cancer and Clinical Pathologic Features.1
341958502021Downregulated expression of IL‑28RA is involved in the pathogenesis of pancreatic ductal adenocarcinoma.0
332695312021Interferon III-related IL28RA variant is associated with rheumatoid arthritis and systemic lupus erythematosus and specific disease sub-phenotypes.1
337513442021Association of TNFRSF1A and IFNLR1 Gene Polymorphisms with the Risk of Developing Breast Cancer and Clinical Pathologic Features.1
341958502021Downregulated expression of IL‑28RA is involved in the pathogenesis of pancreatic ductal adenocarcinoma.0
313662482020Genetic Polymorphisms of the IFNLR1 Gene Correlate with HCV Infection and Biochemical Features of Chronic HCV Patients in Yunnan, China.0
323530852020Differential expression of interferon-lambda receptor 1 splice variants determines the magnitude of the antiviral response induced by interferon-lambda 3 in human immune cells.31
313662482020Genetic Polymorphisms of the IFNLR1 Gene Correlate with HCV Infection and Biochemical Features of Chronic HCV Patients in Yunnan, China.0
323530852020Differential expression of interferon-lambda receptor 1 splice variants determines the magnitude of the antiviral response induced by interferon-lambda 3 in human immune cells.31
317996542019Significance of IL28RA in diagnosis of early pancreatic cancer and its regulation to pancreatic cancer cells by JAK/STAT signaling pathway - effects of IL28RA on pancreatic cancer.4

Citation

Dessen P

IFNLR1 (interferon lambda receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-09-01

Online version: http://atlasgeneticsoncology.org/gene/54864