CYP4F2 (cytochrome P450 family 4 subfamily F member 2)

2014-09-01  

Identity

HGNC
LOCATION
19p13.12
LOCUSID
ALIAS
CPF2

Other Information

Locus ID:

NCBI: 8529
MIM: 604426
HGNC: 2645
Ensembl: ENSG00000186115

Variants:

dbSNP: 8529
ClinVar: 8529
TCGA: ENSG00000186115
COSMIC: CYP4F2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186115ENST00000011989A0A0A0MQR0
ENSG00000186115ENST00000221700P78329
ENSG00000186115ENST00000586927K7EK90
ENSG00000186115ENST00000587671K7EPM0
ENSG00000186115ENST00000589654K7EQI8

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Arachidonic acid metabolismKEGGko00590
Arachidonic acid metabolismKEGGhsa00590
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Arachidonic acid metabolismREACTOMER-HSA-2142753
Synthesis of Leukotrienes (LT) and Eoxins (EX)REACTOMER-HSA-2142691
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)REACTOMER-HSA-2142816
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Cytochrome P450 - arranged by substrate typeREACTOMER-HSA-211897
Fatty acidsREACTOMER-HSA-211935
EicosanoidsREACTOMER-HSA-211979
Miscellaneous substratesREACTOMER-HSA-211958

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA126CYP2C9GeneDataAnnotationassociated
PA130620651anthracyclines and related substancesChemicalClinicalAnnotationassociatedPD21900104, 23441093
PA133787052VKORC1GeneDataAnnotationassociated
PA153619833Peripheral Vascular DiseasesDiseaseClinicalAnnotationassociatedPKPD18250228, 19207028, 19297519, 19300499, 19741565, 19794411, 20072124, 20128861, 20182420, 20421126, 20442691, 20653676, 20833655, 21084764, 21127708, 21174619, 21228733, 21326313, 21383771, 21725053, 22010099, 22130800, 22172097, 22192158, 22528326, 22534826, 22549502, 22676192, 22871975, 23061746, 23104259, 23132553, 23215885, 23949431, 23990957, 24019055, 24029542, 24330000, 24601977, 25042728, 25084205, 25126975, 25594941, 26024874, 26223945, 26257249, 26710337, 26739746, 26745506, 26877068, 27073641, 27121899, 27262824, 27488389, 27617219, 27938396, 28049362, 28262345, 28429387, 28550460, 28620303, 28973620, 29054760, 29201113, 29252193, 29432897, 29875668
PA164713404Vitamin KChemicalClinicalAnnotation, VipGeneassociatedPK27061505, 27462768, 27488389, 28262345, 29252193, 29273767, 18841274, 19297519, 28521079
PA165108401Acute coronary syndromeDiseaseClinicalAnnotationassociatedPD24418943, 25712182
PA165816543CYP2C9*2HaplotypeGuidelineAnnotationassociated
PA165816544CYP2C9*3HaplotypeGuidelineAnnotationassociated
PA165816546CYP2C9*5HaplotypeGuidelineAnnotationassociated
PA165816547CYP2C9*6HaplotypeGuidelineAnnotationassociated
PA165816549CYP2C9*8HaplotypeGuidelineAnnotationassociated
PA165816552CYP2C9*11HaplotypeGuidelineAnnotationassociated
PA165860687CYP4F2*3HaplotypeVipGeneassociated19132230, 20072124, 20182420, 20555338, 22417713, 22855348, 24956252, 25042728, 14638353
PA166122486db-289ChemicalVipGeneassociated
PA166123298over-anticoagulationDiseaseClinicalAnnotationassociatedPD22417713, 23104259, 24911077, 28049362
PA166129532time to therapeutic inrDiseaseVariantAnnotationassociatedPD29396738
PA166154157rs12777823VariantGuidelineAnnotationassociated
PA166155091rs9923231VariantGuidelineAnnotationassociated
PA166155381rs2108622VariantGuidelineAnnotation, VipGeneassociated19132230, 20072124, 20182420, 20555338, 22417713, 22855348, 24956252, 25042728, 14638353
PA166197681Vitamin K1ChemicalClinicalAnnotationassociatedPK31134657
PA28660GGCXGeneDataAnnotationassociated
PA443459Atrial FibrillationDiseaseClinicalAnnotation, VariantAnnotationassociatedPD19270263, 19578179, 22486182, 23510058, 24956252, 25042728, 25519826, 29396738, 29432897, 29479633
PA444417HemorrhageDiseaseClinicalAnnotation, VariantAnnotationassociatedPKPD18250228, 19207028, 19297519, 19300499, 19741565, 19794411, 20072124, 20128861, 20182420, 20421126, 20442691, 20653676, 20833655, 21084764, 21127708, 21174619, 21228733, 21326313, 21383771, 21725053, 22010099, 22130800, 22172097, 22192158, 22528326, 22534826, 22549502, 22676192, 22871975, 23061746, 23104259, 23132553, 23215885, 23949431, 23990957, 24019055, 24029542, 24330000, 24601977, 25042728, 25084205, 25126975, 25594941, 26024874, 26223945, 26257249, 26710337, 26739746, 26745506, 26877068, 27073641, 27121899, 27262824, 27488389, 27617219, 27938396, 28049362, 28262345, 28429387, 28550460, 28620303, 28973620, 29054760, 29201113, 29252193, 29432897, 29875668
PA445019Myocardial InfarctionDiseaseClinicalAnnotationassociatedPKPD18250228, 19207028, 19297519, 19300499, 19741565, 19794411, 20072124, 20128861, 20182420, 20421126, 20442691, 20653676, 20833655, 21084764, 21127708, 21174619, 21228733, 21326313, 21383771, 21725053, 22010099, 22130800, 22172097, 22192158, 22528326, 22534826, 22549502, 22676192, 22871975, 23061746, 23104259, 23132553, 23215885, 23949431, 23990957, 24019055, 24029542, 24330000, 24601977, 25042728, 25084205, 25126975, 25594941, 26024874, 26223945, 26257249, 26710337, 26739746, 26745506, 26877068, 27073641, 27121899, 27262824, 27488389, 27617219, 27938396, 28049362, 28262345, 28429387, 28550460, 28620303, 28973620, 29054760, 29201113, 29252193, 29432897, 29875668
PA445062NeoplasmsDiseaseClinicalAnnotationassociatedPD21900104, 23441093
PA445848ThromboembolismDiseaseClinicalAnnotationassociatedPKPD18250228, 19207028, 19297519, 19300499, 19741565, 19794411, 20072124, 20128861, 20182420, 20421126, 20442691, 20653676, 20833655, 21084764, 21127708, 21174619, 21228733, 21326313, 21383771, 21725053, 22010099, 22130800, 22172097, 22192158, 22528326, 22534826, 22549502, 22676192, 22871975, 23061746, 23104259, 23132553, 23215885, 23949431, 23990957, 24019055, 24029542, 24330000, 24601977, 25042728, 25084205, 25126975, 25594941, 26024874, 26223945, 26257249, 26710337, 26739746, 26745506, 26877068, 27073641, 27121899, 27262824, 27488389, 27617219, 27938396, 28049362, 28262345, 28429387, 28550460, 28620303, 28973620, 29054760, 29201113, 29252193, 29432897, 29875668
PA446997Intracranial HemorrhagesDiseaseClinicalAnnotationassociatedPKPD18250228, 19207028, 19297519, 19300499, 19741565, 19794411, 20072124, 20128861, 20182420, 20421126, 20442691, 20653676, 20833655, 21084764, 21127708, 21174619, 21228733, 21326313, 21383771, 21725053, 22010099, 22130800, 22172097, 22192158, 22528326, 22534826, 22549502, 22676192, 22871975, 23061746, 23104259, 23132553, 23215885, 23949431, 23990957, 24019055, 24029542, 24330000, 24601977, 25042728, 25084205, 25126975, 25594941, 26024874, 26223945, 26257249, 26710337, 26739746, 26745506, 26877068, 27073641, 27121899, 27262824, 27488389, 27617219, 27938396, 28049362, 28262345, 28429387, 28550460, 28620303, 28973620, 29054760, 29201113, 29252193, 29432897, 29875668
PA447288Essential hypertensionDiseaseVipGeneassociated18971550
PA447298venous thromboembolismDiseaseClinicalAnnotationassociatedPKPD18250228, 19207028, 19297519, 19300499, 19741565, 19794411, 20072124, 20128861, 20182420, 20421126, 20442691, 20653676, 20833655, 21084764, 21127708, 21174619, 21228733, 21326313, 21383771, 21725053, 22010099, 22130800, 22172097, 22192158, 22528326, 22534826, 22549502, 22676192, 22871975, 23061746, 23104259, 23132553, 23215885, 23949431, 23990957, 24019055, 24029542, 24330000, 24601977, 25042728, 25084205, 25126975, 25594941, 26024874, 26223945, 26257249, 26710337, 26739746, 26745506, 26877068, 27073641, 27121899, 27262824, 27488389, 27617219, 27938396, 28049362, 28262345, 28429387, 28550460, 28620303, 28973620, 29054760, 29201113, 29252193, 29432897, 29875668
PA448497aspirinChemicalClinicalAnnotationassociatedPD24418943, 25712182
PA449045clofibrateChemicalVipGeneassociated11061988, 11997390, 15753130, 17142457, 10860554
PA449053clopidogrelChemicalClinicalAnnotationassociatedPD24418943, 25712182
PA450146ketoconazoleChemicalVipGeneassociated15753130
PA450272lovastatinChemicalVipGeneassociated17142457
PA450921phenprocoumonChemicalClinicalAnnotationassociatedPKPD21063236, 23510058
PA451900vitamin eChemicalClinicalAnnotation, VipGeneassociatedPK15753130, 18433732, 11997390, 17341693, 20861217, 24138531, 24759732
PA451906warfarinChemicalClinicalAnnotation, DataAnnotation, GuidelineAnnotation, Literature, MultilinkAnnotation, VariantAnnotation, VipGeneambiguousPKPD18391101, 18971550, 24984178, 27061505, 27462768, 27488389, 28262345, 29252193, 29273767, 17341693, 18250228, 19207028, 19297519, 19300499, 19741565, 19794411, 20072124, 20128861, 20182420, 20421126, 20442691, 20653676, 20833655, 21084764, 21127708, 21174619, 21228733, 21326313, 21383771, 21725053, 22010099, 22130800, 22172097, 22192158, 22417713, 22528326, 22534826, 22549502, 22676192, 22871975, 23061746, 23104259, 23132553, 23215885, 23949431, 23990957, 24019055, 24029542, 24330000, 24601977, 24911077, 25042728, 25084205, 25126975, 25594941, 26024874, 26223945, 26257249, 26710337, 26739746, 26745506, 26877068, 27073641, 27121899, 27262824, 27488389, 27617219, 27938396, 28049362, 28079798, 28262345, 28429387, 28550460, 28620303, 28973620, 29054760, 29201113, 29252193, 29396738, 29432897, 29875668
PA452632acenocoumarolChemicalClinicalAnnotation, DataAnnotation, Literature, VipGeneassociatedPD27061505, 27462768, 27488389, 28262345, 29252193, 29273767, 19132230, 19270263, 19578179, 22486182, 23510058, 24956252, 25042728, 25089947, 25519826, 29432897, 29479633
PA55APOEGeneDataAnnotationassociated

References

Pubmed IDYearTitleCitations
366341012023Suggestive evidence of CYP4F2 gene polymorphisms with HAPE susceptibility in the Chinese Han population.2
367587222023The frequency of cytochrome 4F2 rs2108622 genetic variant and its effects on the lipid profile and complications of type II diabetes among a sample of patients in Jordan: A pilot study.0
371215482023CYP4F2 is a human-specific determinant of circulating N-acyl amino acid levels.1
371613132023Computational analysis of missense variant CYP4F2*3 (V433M) in association with human CYP4F2 dysfunction: a functional and structural impact.1
375051712023Frequency of polymorphisms in the CYP2C9, VKORC1, and CYP4F2 genes related to the metabolism of Warfarin in healthy donors from Cali, Colombia.0
376537962023Association among VKORC1 rs9923231, CYP4F2 rs2108622, GGCX rs11676382 polymorphisms and acute ischemic stroke.0
377753332023Functional Characterization of 29 Cytochrome P450 4F2 Variants Identified in a Population of 8380 Japanese Subjects and Assessment of Arachidonic Acid ω-Hydroxylation.0
366341012023Suggestive evidence of CYP4F2 gene polymorphisms with HAPE susceptibility in the Chinese Han population.2
367587222023The frequency of cytochrome 4F2 rs2108622 genetic variant and its effects on the lipid profile and complications of type II diabetes among a sample of patients in Jordan: A pilot study.0
371215482023CYP4F2 is a human-specific determinant of circulating N-acyl amino acid levels.1
371613132023Computational analysis of missense variant CYP4F2*3 (V433M) in association with human CYP4F2 dysfunction: a functional and structural impact.1
375051712023Frequency of polymorphisms in the CYP2C9, VKORC1, and CYP4F2 genes related to the metabolism of Warfarin in healthy donors from Cali, Colombia.0
376537962023Association among VKORC1 rs9923231, CYP4F2 rs2108622, GGCX rs11676382 polymorphisms and acute ischemic stroke.0
377753332023Functional Characterization of 29 Cytochrome P450 4F2 Variants Identified in a Population of 8380 Japanese Subjects and Assessment of Arachidonic Acid ω-Hydroxylation.0
343026322022The association study between CYP20A1, CYP4F2, CYP2D6 gene polymorphisms and coronary heart disease risk in the Han population in southern China.2

Citation

Dessen P

CYP4F2 (cytochrome P450 family 4 subfamily F member 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-09-01

Online version: http://atlasgeneticsoncology.org/gene/54891/meetings/gene-explorer/css/lib/dataTables.bootstrap.min.css