CALM2 (calmodulin 2)

2014-10-01 Affiliation

Identity

HGNC

CALM2

LOCATION

2p21

LOCUSID

805

ALIAS

CALM,CALML2,CAM1,CAM3,CAMC,CAMII,CAMIII,LQT15,PHKD,PHKD2,caM

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 805
MIM: 114182
HGNC: 1445
Ensembl: ENSG00000143933

Variants:

dbSNP: 805
ClinVar: 805
TCGA: ENSG00000143933
COSMIC: CALM2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000143933	ENST00000272298	P0DP24
ENSG00000143933	ENST00000272298	B4DJ51
ENSG00000143933	ENST00000409563	E7EMB3
ENSG00000143933	ENST00000432899	F8WBR5
ENSG00000143933	ENST00000456319	Q96HY3
ENSG00000143933	ENST00000484408	A0A590UJI2
ENSG00000143933	ENST00000489742	A0A590UJC0
ENSG00000143933	ENST00000628793	M0QZ52
ENSG00000143933	ENST00000652974	A0A590UJE2
ENSG00000143933	ENST00000654798	P0DP24
ENSG00000143933	ENST00000654798	B4DJ51
ENSG00000143933	ENST00000655450	Q96HY3
ENSG00000143933	ENST00000655728	Q96HY3
ENSG00000143933	ENST00000656538	Q96HY3
ENSG00000143933	ENST00000668667	Q96HY3

Expression (GTEx)

500

1000

1500

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Calcium signaling pathway	KEGG	ko04020
Phosphatidylinositol signaling system	KEGG	ko04070
Long-term potentiation	KEGG	ko04720
Olfactory transduction	KEGG	ko04740
Insulin signaling pathway	KEGG	ko04910
GnRH signaling pathway	KEGG	ko04912
Melanogenesis	KEGG	ko04916
Alzheimer's disease	KEGG	ko05010
Glioma	KEGG	ko05214
Calcium signaling pathway	KEGG	hsa04020
Phosphatidylinositol signaling system	KEGG	hsa04070
Long-term potentiation	KEGG	hsa04720
Olfactory transduction	KEGG	hsa04740
Insulin signaling pathway	KEGG	hsa04910
GnRH signaling pathway	KEGG	hsa04912
Melanogenesis	KEGG	hsa04916
Alzheimer's disease	KEGG	hsa05010
Glioma	KEGG	hsa05214
Vascular smooth muscle contraction	KEGG	hsa04270
Vascular smooth muscle contraction	KEGG	ko04270
Neurotrophin signaling pathway	KEGG	ko04722
Neurotrophin signaling pathway	KEGG	hsa04722
Oocyte meiosis	KEGG	ko04114
Oocyte meiosis	KEGG	hsa04114
Phototransduction	KEGG	ko04744
Phototransduction	KEGG	hsa04744
Salivary secretion	KEGG	ko04970
Salivary secretion	KEGG	hsa04970
Gastric acid secretion	KEGG	ko04971
Gastric acid secretion	KEGG	hsa04971
Tuberculosis	KEGG	ko05152
Tuberculosis	KEGG	hsa05152
Pertussis	KEGG	ko05133
Pertussis	KEGG	hsa05133
Dopaminergic synapse	KEGG	ko04728
Dopaminergic synapse	KEGG	hsa04728
Amphetamine addiction	KEGG	hsa05031
Amphetamine addiction	KEGG	ko05031
Alcoholism	KEGG	hsa05034
Alcoholism	KEGG	ko05034
Circadian entrainment	KEGG	hsa04713
Circadian entrainment	KEGG	ko04713
Estrogen signaling pathway	KEGG	hsa04915
Estrogen signaling pathway	KEGG	ko04915
Ras signaling pathway	KEGG	hsa04014
Rap1 signaling pathway	KEGG	hsa04015
Rap1 signaling pathway	KEGG	ko04015
Adrenergic signaling in cardiomyocytes	KEGG	hsa04261
Adrenergic signaling in cardiomyocytes	KEGG	ko04261
Inflammatory mediator regulation of TRP channels	KEGG	hsa04750
Inflammatory mediator regulation of TRP channels	KEGG	ko04750
Oxytocin signaling pathway	KEGG	hsa04921
Oxytocin signaling pathway	KEGG	ko04921
cGMP-PKG signaling pathway	KEGG	hsa04022
cGMP-PKG signaling pathway	KEGG	ko04022
cAMP signaling pathway	KEGG	hsa04024
cAMP signaling pathway	KEGG	ko04024
Glucagon signaling pathway	KEGG	hsa04922
Glucagon signaling pathway	KEGG	ko04922
Renin secretion	KEGG	hsa04924
Renin secretion	KEGG	ko04924
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Neuronal System	REACTOME	R-HSA-112316
Transmission across Chemical Synapses	REACTOME	R-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	REACTOME	R-HSA-112314
Activation of NMDA receptor upon glutamate binding and postsynaptic events	REACTOME	R-HSA-442755
Post NMDA receptor activation events	REACTOME	R-HSA-438064
CREB phosphorylation through the activation of Ras	REACTOME	R-HSA-442742
Ras activation uopn Ca2+ infux through NMDA receptor	REACTOME	R-HSA-442982
CREB phosphorylation through the activation of CaMKII	REACTOME	R-HSA-442729
CREB phosphorylation through the activation of CaMKK	REACTOME	R-HSA-442717
Activation of CaMK IV	REACTOME	R-HSA-442745
Activation of Kainate Receptors upon glutamate binding	REACTOME	R-HSA-451326
Ionotropic activity of Kainate Receptors	REACTOME	R-HSA-451306
Activation of Ca-permeable Kainate Receptor	REACTOME	R-HSA-451308
Disease	REACTOME	R-HSA-1643685
Infectious disease	REACTOME	R-HSA-5663205
Uptake and actions of bacterial toxins	REACTOME	R-HSA-5339562
Uptake and function of anthrax toxins	REACTOME	R-HSA-5210891
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Signaling by the B Cell Receptor (BCR)	REACTOME	R-HSA-983705
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	REACTOME	R-HSA-983695
Innate Immune System	REACTOME	R-HSA-168249
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491
RAF/MAP kinase cascade	REACTOME	R-HSA-5673001
DAG and IP3 signaling	REACTOME	R-HSA-1489509
CaM pathway	REACTOME	R-HSA-111997
Calmodulin induced events	REACTOME	R-HSA-111933
CaMK IV-mediated phosphorylation of CREB	REACTOME	R-HSA-111932
Cam-PDE 1 activation	REACTOME	R-HSA-111957
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
FCERI mediated MAPK activation	REACTOME	R-HSA-2871796
FCERI mediated Ca+2 mobilization	REACTOME	R-HSA-2871809
C-type lectin receptors (CLRs)	REACTOME	R-HSA-5621481
CLEC7A (Dectin-1) signaling	REACTOME	R-HSA-5607764
CLEC7A (Dectin-1) induces NFAT activation	REACTOME	R-HSA-5607763
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-2 signaling	REACTOME	R-HSA-451927
Interleukin receptor SHC signaling	REACTOME	R-HSA-912526
Interleukin-3, 5 and GM-CSF signaling	REACTOME	R-HSA-512988
Hemostasis	REACTOME	R-HSA-109582
Platelet homeostasis	REACTOME	R-HSA-418346
Platelet calcium homeostasis	REACTOME	R-HSA-418360
Reduction of cytosolic Ca++ levels	REACTOME	R-HSA-418359
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
Response to elevated platelet cytosolic Ca2+	REACTOME	R-HSA-76005
Platelet degranulation	REACTOME	R-HSA-114608
Signal Transduction	REACTOME	R-HSA-162582
Signaling by EGFR	REACTOME	R-HSA-177929
EGFR interacts with phospholipase C-gamma	REACTOME	R-HSA-212718
GRB2 events in EGFR signaling	REACTOME	R-HSA-179812
SHC1 events in EGFR signaling	REACTOME	R-HSA-180336
Signaling by Insulin receptor	REACTOME	R-HSA-74752
Insulin receptor signalling cascade	REACTOME	R-HSA-74751
IRS-mediated signalling	REACTOME	R-HSA-112399
SOS-mediated signalling	REACTOME	R-HSA-112412
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
Signalling to ERKs	REACTOME	R-HSA-187687
Signalling to RAS	REACTOME	R-HSA-167044
Signalling to p38 via RIT and RIN	REACTOME	R-HSA-187706
Prolonged ERK activation events	REACTOME	R-HSA-169893
Frs2-mediated activation	REACTOME	R-HSA-170968
ARMS-mediated activation	REACTOME	R-HSA-170984
PLC-gamma1 signalling	REACTOME	R-HSA-167021
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Signaling by VEGF	REACTOME	R-HSA-194138
VEGFA-VEGFR2 Pathway	REACTOME	R-HSA-4420097
VEGFR2 mediated vascular permeability	REACTOME	R-HSA-5218920
VEGFR2 mediated cell proliferation	REACTOME	R-HSA-5218921
Signaling by SCF-KIT	REACTOME	R-HSA-1433557
MAPK family signaling cascades	REACTOME	R-HSA-5683057
MAPK1/MAPK3 signaling	REACTOME	R-HSA-5684996
Signaling by Rho GTPases	REACTOME	R-HSA-194315
RHO GTPase Effectors	REACTOME	R-HSA-195258
RHO GTPases activate PAKs	REACTOME	R-HSA-5627123
RHO GTPases activate IQGAPs	REACTOME	R-HSA-5626467
Signaling by GPCR	REACTOME	R-HSA-372790
Opioid Signalling	REACTOME	R-HSA-111885
G-protein mediated events	REACTOME	R-HSA-112040
PLC beta mediated events	REACTOME	R-HSA-112043
Ca-dependent events	REACTOME	R-HSA-111996
DARPP-32 events	REACTOME	R-HSA-180024
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
Signaling by Wnt	REACTOME	R-HSA-195721
Beta-catenin independent WNT signaling	REACTOME	R-HSA-3858494
Ca2+ pathway	REACTOME	R-HSA-4086398
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	REACTOME	R-HSA-2404192
IGF1R signaling cascade	REACTOME	R-HSA-2428924
IRS-related events triggered by IGF1R	REACTOME	R-HSA-2428928
Visual phototransduction	REACTOME	R-HSA-2187338
The phototransduction cascade	REACTOME	R-HSA-2514856
Inactivation, recovery and regulation of the phototransduction cascade	REACTOME	R-HSA-2514859
Signaling by Leptin	REACTOME	R-HSA-2586552
Muscle contraction	REACTOME	R-HSA-397014
Smooth Muscle Contraction	REACTOME	R-HSA-445355
Vesicle-mediated transport	REACTOME	R-HSA-5653656
Membrane Trafficking	REACTOME	R-HSA-199991
Translocation of GLUT4 to the plasma membrane	REACTOME	R-HSA-1445148
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
SLC-mediated transmembrane transport	REACTOME	R-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptides	REACTOME	R-HSA-425393
Sodium/Calcium exchangers	REACTOME	R-HSA-425561
Ion channel transport	REACTOME	R-HSA-983712
Ion transport by P-type ATPases	REACTOME	R-HSA-936837
Stimuli-sensing channels	REACTOME	R-HSA-2672351
Metabolism	REACTOME	R-HSA-1430728
Metabolism of carbohydrates	REACTOME	R-HSA-71387
Glucose metabolism	REACTOME	R-HSA-70326
Glycogen breakdown (glycogenolysis)	REACTOME	R-HSA-70221
Inositol phosphate metabolism	REACTOME	R-HSA-1483249
Synthesis of IP3 and IP4 in the cytosol	REACTOME	R-HSA-1855204
Metabolism of nitric oxide	REACTOME	R-HSA-202131
eNOS activation and regulation	REACTOME	R-HSA-203765
eNOS activation	REACTOME	R-HSA-203615
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	REACTOME	R-HSA-1474151
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
NCAM signaling for neurite out-growth	REACTOME	R-HSA-375165
Aldosterone synthesis and secretion	KEGG	hsa04925
Aldosterone synthesis and secretion	KEGG	ko04925
Cardiac conduction	REACTOME	R-HSA-5576891
Phase 0 - rapid depolarisation	REACTOME	R-HSA-5576892
Ion homeostasis	REACTOME	R-HSA-5578775
RET signaling	REACTOME	R-HSA-8853659
Protein methylation	REACTOME	R-HSA-8876725
Fluid shear stress and atherosclerosis	KEGG	ko05418
Fluid shear stress and atherosclerosis	KEGG	hsa05418
Apelin signaling pathway	KEGG	hsa04371

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
38754328	2024	Calmodulin 2 expression is associated with poor prognosis in breast cancer.	0
38754328	2024	Calmodulin 2 expression is associated with poor prognosis in breast cancer.	0
37380439	2023	Calmodulinopathy in Japanese Children　- Their Cardiac Phenotypes Are Severe and Show Early Onset in Fetal Life and Infancy.	0
37470336	2023	microRNA-651-5p affects the proliferation, migration, and invasion of lung cancer cells by regulating Calmodulin 2 expression.	2
37380439	2023	Calmodulinopathy in Japanese Children　- Their Cardiac Phenotypes Are Severe and Show Early Onset in Fetal Life and Infancy.	0
37470336	2023	microRNA-651-5p affects the proliferation, migration, and invasion of lung cancer cells by regulating Calmodulin 2 expression.	2
33788723	2021	Targeting CALM2 Inhibits Hepatocellular Carcinoma Growth and Metastasis by Suppressing E2F5-mediated Cell Cycle Progression.	4
33951696	2021	Circular RNA circ_0010729 Knockdown Attenuates Oxygen-Glucose Deprivation-Induced Human Cardiac Myocytes Injury by miR-338-3p/CALM2 Axis.	3
33788723	2021	Targeting CALM2 Inhibits Hepatocellular Carcinoma Growth and Metastasis by Suppressing E2F5-mediated Cell Cycle Progression.	4
33951696	2021	Circular RNA circ_0010729 Knockdown Attenuates Oxygen-Glucose Deprivation-Induced Human Cardiac Myocytes Injury by miR-338-3p/CALM2 Axis.	3
33191766	2020	Prevalence and Phenotypic Correlations of Calmodulinopathy-Causative CALM1-3 Variants Detected in a Multicenter Molecular Autopsy Cohort of Sudden Unexplained Death Victims.	1
33191766	2020	Prevalence and Phenotypic Correlations of Calmodulinopathy-Causative CALM1-3 Variants Detected in a Multicenter Molecular Autopsy Cohort of Sudden Unexplained Death Victims.	1
30317608	2019	Identification of TAF1, HNF4A, and CALM2 as potential therapeutic target genes for liver fibrosis.	13
30317608	2019	Identification of TAF1, HNF4A, and CALM2 as potential therapeutic target genes for liver fibrosis.	13
29932249	2018	Protein phenotype diagnosis of autosomal dominant calmodulin mutations causing irregular heart rhythms.	5

Citation

Dessen P

CALM2 (calmodulin 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-10-01

Online version: http://atlasgeneticsoncology.org/gene/54927