GRK5 (G protein-coupled receptor kinase 5)

2014-11-01  

Identity

HGNC
GRK5
LOCATION
10q26.11
LOCUSID
2869
ALIAS
FP2025,GPRK5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2869
MIM: 600870
HGNC: 4544
Ensembl: ENSG00000198873

Variants:

dbSNP: 2869
ClinVar: 2869
TCGA: ENSG00000198873
COSMIC: GRK5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198873ENST00000392870P34947

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Morphine addictionKEGGhsa05032
Morphine addictionKEGGko05032
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10074escitalopramChemicalClinicalAnnotationassociatedPD
PA164712445AntihypertensivesChemicalClinicalAnnotationassociatedPD18425130, 21127457
PA164712535Beta Blocking AgentsChemicalClinicalAnnotationassociatedPD18425130, 21127457
PA444368Heart DiseasesDiseaseClinicalAnnotationassociatedPD18425130, 21127457
PA444370Heart FailureDiseaseClinicalAnnotationassociatedPD
PA447207Depressive DisorderDiseaseClinicalAnnotationassociatedPD
PA449015citalopramChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
382061792024GRK5 promoted renal fibrosis via HDAC5/Smad3 signaling pathway.0
388225442024Association of GRK5 variant rs10886471 with the therapeutic effect of repaglinide in patients of type 2 diabetes mellitus in Peshawar, Pakistan.0
382061792024GRK5 promoted renal fibrosis via HDAC5/Smad3 signaling pathway.0
388225442024Association of GRK5 variant rs10886471 with the therapeutic effect of repaglinide in patients of type 2 diabetes mellitus in Peshawar, Pakistan.0
365845712023Genetic Arg-304-His substitution in GRK5 protects against sepsis progression by alleviating NF-κB-mediated inflammation.1
365845712023Genetic Arg-304-His substitution in GRK5 protects against sepsis progression by alleviating NF-κB-mediated inflammation.1
348711842022Polymorphic Variants in the GRK5 Gene Promoter Are Associated With Diastolic Dysfunction in Coronary Artery Bypass Graft Surgery Patients.1
354129542022lncRNA LINC01315 promotes malignancy of triple-negative breast cancer and predicts poor outcomes by modulating microRNA-876-5p/GRK5.5
348711842022Polymorphic Variants in the GRK5 Gene Promoter Are Associated With Diastolic Dysfunction in Coronary Artery Bypass Graft Surgery Patients.1
354129542022lncRNA LINC01315 promotes malignancy of triple-negative breast cancer and predicts poor outcomes by modulating microRNA-876-5p/GRK5.5
333210952021Structure of a GRK5-Calmodulin Complex Reveals Molecular Mechanism of GRK Activation and Substrate Targeting.8
334668002021GRKs and Epac1 Interaction in Cardiac Remodeling and Heart Failure.4
342689292021Association between gene polymorphism of GRK5 and breast cancer risk in Chinese population.1
333210952021Structure of a GRK5-Calmodulin Complex Reveals Molecular Mechanism of GRK Activation and Substrate Targeting.8
334668002021GRKs and Epac1 Interaction in Cardiac Remodeling and Heart Failure.4

Citation

Dessen P

GRK5 (G protein-coupled receptor kinase 5)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/54940