CPSF4 (cleavage and polyadenylation specific factor 4)

2014-11-01  

Identity

HGNC
CPSF4
LOCATION
7q22.1
LOCUSID
10898
ALIAS
CPSF30,NAR,NEB-1,NEB1

Other Information

Locus ID:

NCBI: 10898
MIM: 603052
HGNC: 2327
Ensembl: ENSG00000160917

Variants:

dbSNP: 10898
ClinVar: 10898
TCGA: ENSG00000160917
COSMIC: CPSF4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160917ENST00000292476O95639
ENSG00000160917ENST00000412686C9K0K2
ENSG00000160917ENST00000430038F8WEL7
ENSG00000160917ENST00000436336O95639
ENSG00000160917ENST00000440514H7C419
ENSG00000160917ENST00000441580B7Z7B0
ENSG00000160917ENST00000451876C9JEV9
ENSG00000160917ENST00000452047H7C016

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015
Influenza AKEGGko05164
Influenza AKEGGhsa05164
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
Influenza InfectionREACTOMER-HSA-168254
Host Interactions with Influenza FactorsREACTOMER-HSA-168253
NS1 Mediated Effects on Host PathwaysREACTOMER-HSA-168276
Inhibition of Host mRNA Processing and RNA SilencingREACTOMER-HSA-168315
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Transcription TerminationREACTOMER-HSA-73856
Cleavage of Growing Transcript in the Termination RegionREACTOMER-HSA-109688
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
mRNA 3'-end processingREACTOMER-HSA-72187
Transport of Mature Transcript to CytoplasmREACTOMER-HSA-72202
Transport of Mature mRNAs Derived from Intronless TranscriptsREACTOMER-HSA-159234
Transport of Mature mRNA Derived from an Intronless TranscriptREACTOMER-HSA-159231
Processing of Capped Intronless Pre-mRNAREACTOMER-HSA-75067
Processing of Intronless Pre-mRNAsREACTOMER-HSA-77595
tRNA processingREACTOMER-HSA-72306
tRNA processing in the nucleusREACTOMER-HSA-6784531

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
376291422023Cleavage and Polyadenylation-Specific Factor 4 (CPSF4) Expression Is Associated with Enhanced Prostate Cancer Cell Migration and Cell Cycle Dysregulation, In Vitro.0
376291422023Cleavage and Polyadenylation-Specific Factor 4 (CPSF4) Expression Is Associated with Enhanced Prostate Cancer Cell Migration and Cell Cycle Dysregulation, In Vitro.0
365674172022CPSF4 promotes tumor-initiating phenotype by enhancing VEGF/NRP2/TAZ signaling in lung cancer.1
365674172022CPSF4 promotes tumor-initiating phenotype by enhancing VEGF/NRP2/TAZ signaling in lung cancer.1
335350572021Overproduced CPSF4 Promotes Cell Proliferation and Invasion via PI3K-AKT Signaling Pathway in Oral Squamous Cell Carcinoma.6
340068502021CPSF4 promotes triple negative breast cancer metastasis by upregulating MDM4.2
341036822021CPSF4 regulates circRNA formation and microRNA mediated gene silencing in hepatocellular carcinoma.6
335350572021Overproduced CPSF4 Promotes Cell Proliferation and Invasion via PI3K-AKT Signaling Pathway in Oral Squamous Cell Carcinoma.6
340068502021CPSF4 promotes triple negative breast cancer metastasis by upregulating MDM4.2
341036822021CPSF4 regulates circRNA formation and microRNA mediated gene silencing in hepatocellular carcinoma.6
309702202019MiR-4458 inhibits breast cancer cell growth, migration, and invasiveness by targeting CPSF4.18
309702202019MiR-4458 inhibits breast cancer cell growth, migration, and invasiveness by targeting CPSF4.18
285540592017Residues F103 and M106 within the influenza A virus NS1 CPSF4-binding region regulate interferon-stimulated gene translation initiation.4
292742312017Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex.48
285540592017Residues F103 and M106 within the influenza A virus NS1 CPSF4-binding region regulate interferon-stimulated gene translation initiation.4

Citation

Dessen P

CPSF4 (cleavage and polyadenylation specific factor 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/54950/gc-cpsf4