CBX2 (chromobox 2)

2015-02-01  

Identity

HGNC
LOCATION
17q25.3
LOCUSID
ALIAS
CDCA6,M33,SRXY5
FUSION GENES

Other Information

Locus ID:

NCBI: 84733
MIM: 602770
HGNC: 1552
Ensembl: ENSG00000173894

Variants:

dbSNP: 84733
ClinVar: 84733
TCGA: ENSG00000173894
COSMIC: CBX2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173894ENST00000269399Q14781
ENSG00000173894ENST00000310942Q14781

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
SUMOylation of DNA damage response and repair proteinsREACTOMER-HSA-3108214
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Oxidative Stress Induced SenescenceREACTOMER-HSA-2559580
SUMOylation of RNA binding proteinsREACTOMER-HSA-4570464

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
375534502024Subcellular expression pattern and clinical significance of CBX2 and CBX7 in breast cancer subtypes.0
383554802024Cuproptosis-related ceRNA axis triggers cell proliferation and cell cycle through CBX2 in lung adenocarcinoma.0
375534502024Subcellular expression pattern and clinical significance of CBX2 and CBX7 in breast cancer subtypes.0
383554802024Cuproptosis-related ceRNA axis triggers cell proliferation and cell cycle through CBX2 in lung adenocarcinoma.0
366219792023Loss of CBX2 causes genomic instability and Wnt activation in high grade serous ovarian carcinoma cells.1
371966092023MiR-30a-5p inhibits cell behaviors in esophageal cancer via modulating CBX2.1
379801632023Prognostic hub gene CBX2 drives a cancer stem cell-like phenotype in HCC revealed by multi-omics and multi-cohorts.0
380306042023Phosphorylation of USP27X by GSK3β maintains the stability and oncogenic functions of CBX2.0
366219792023Loss of CBX2 causes genomic instability and Wnt activation in high grade serous ovarian carcinoma cells.1
371966092023MiR-30a-5p inhibits cell behaviors in esophageal cancer via modulating CBX2.1
379801632023Prognostic hub gene CBX2 drives a cancer stem cell-like phenotype in HCC revealed by multi-omics and multi-cohorts.0
380306042023Phosphorylation of USP27X by GSK3β maintains the stability and oncogenic functions of CBX2.0
352637542022CBX2 in DSD: The Quirky Kid on the Block.2
353857442022Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-Cbx2 axis.9
356812352022CBX2 shapes chromatin accessibility promoting AML via p38 MAPK signaling pathway.15

Citation

Dessen P

CBX2 (chromobox 2)

Atlas Genet Cytogenet Oncol Haematol. 2015-02-01

Online version: http://atlasgeneticsoncology.org/gene/54967/meetings/css/deep-insight-explorer/