AGRP (agouti related neuropeptide)

2015-02-01  

Identity

HGNC
AGRP
LOCATION
16q22.1
LOCUSID
181
ALIAS
AGRT,ART,ASIP2

Other Information

Locus ID:

NCBI: 181
MIM: 602311
HGNC: 330
Ensembl: ENSG00000159723

Variants:

dbSNP: 181
ClinVar: 181
TCGA: ENSG00000159723
COSMIC: AGRP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000159723ENST00000290953O00253
ENSG00000159723ENST00000290953C6SUN5

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Adipocytokine signaling pathwayKEGGko04920
Adipocytokine signaling pathwayKEGGhsa04920

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
hypothalamus
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
365778442023AgRP neurons coordinate the mitigation of activity-based anorexia.6
367651312023Nuclear receptor 5A2 regulation of Agrp underlies olanzapine-induced hyperphagia.0
365778442023AgRP neurons coordinate the mitigation of activity-based anorexia.6
367651312023Nuclear receptor 5A2 regulation of Agrp underlies olanzapine-induced hyperphagia.0
334700982021Discovery of Molecular Interactions of the Human Melanocortin-4 Receptor (hMC4R) Asp189 (D189) Amino Acid with the Endogenous G-Protein-Coupled Receptor (GPCR) Antagonist Agouti-Related Protein (AGRP) Provides Insights to AGRP's Inverse Agonist Pharmacology at the hMC4R.2
334700982021Discovery of Molecular Interactions of the Human Melanocortin-4 Receptor (hMC4R) Asp189 (D189) Amino Acid with the Endogenous G-Protein-Coupled Receptor (GPCR) Antagonist Agouti-Related Protein (AGRP) Provides Insights to AGRP's Inverse Agonist Pharmacology at the hMC4R.2
324141362020Mitochondrial Dynamics and Microglia as New Targets in Metabolism Regulation.12
324141362020Mitochondrial Dynamics and Microglia as New Targets in Metabolism Regulation.12
305970302019Plasma Agouti-Related Protein and Cortisol Levels in Cushing Disease: Evidence for the Regulation of Agouti-Related Protein by Glucocorticoids in Humans.7
313613032019Plasma Agouti-Related Protein Levels in Acromegaly and Effects of Surgical or Pegvisomant Therapy.5
305970302019Plasma Agouti-Related Protein and Cortisol Levels in Cushing Disease: Evidence for the Regulation of Agouti-Related Protein by Glucocorticoids in Humans.7
313613032019Plasma Agouti-Related Protein Levels in Acromegaly and Effects of Surgical or Pegvisomant Therapy.5
282649292017The agouti-related peptide binds heparan sulfate through segments critical for its orexigenic effects.4
282649292017The agouti-related peptide binds heparan sulfate through segments critical for its orexigenic effects.4
262269732016Analysis of MC4R rs17782313, POMC rs1042571, APOE-Hha1 and AGRP rs3412352 genetic variants with susceptibility to obesity risk in North Indians.5

Citation

Dessen P

AGRP (agouti related neuropeptide)

Atlas Genet Cytogenet Oncol Haematol. 2015-02-01

Online version: http://atlasgeneticsoncology.org/gene/55051