SPSB1 (splA/ryanodine receptor domain and SOCS box containing 1)

2015-03-01  

Identity

HGNC
SPSB1
LOCATION
1p36.22
LOCUSID
80176
ALIAS
SSB-1,SSB1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 80176
MIM: 611657
HGNC: 30628
Ensembl: ENSG00000171621

Variants:

dbSNP: 80176
ClinVar: 80176
TCGA: ENSG00000171621
COSMIC: SPSB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171621ENST00000328089Q96BD6
ENSG00000171621ENST00000328089A0A024R4G8
ENSG00000171621ENST00000357898Q96BD6
ENSG00000171621ENST00000357898A0A024R4G8
ENSG00000171621ENST00000377399Q96BD6
ENSG00000171621ENST00000377399A0A024R4G8
ENSG00000171621ENST00000450402A2A276

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

References

Pubmed IDYearTitleCitations
325768122020SUMOylation stabilizes hSSB1 and enhances the recruitment of NBS1 to DNA damage sites.16
325768122020SUMOylation stabilizes hSSB1 and enhances the recruitment of NBS1 to DNA damage sites.16
307129442019SPSB1 enhances ovarian cancer cell survival by destabilizing p21.8
316072072019The E3 Ligases Spsb1 and Spsb4 Regulate RevErbα Degradation and Circadian Period.1
320386382019Cullin-5 Adaptor SPSB1 Controls NF-κB Activation Downstream of Multiple Signaling Pathways.5
307129442019SPSB1 enhances ovarian cancer cell survival by destabilizing p21.8
316072072019The E3 Ligases Spsb1 and Spsb4 Regulate RevErbα Degradation and Circadian Period.1
320386382019Cullin-5 Adaptor SPSB1 Controls NF-κB Activation Downstream of Multiple Signaling Pathways.5
280843292017SPSB1-mediated HnRNP A1 ubiquitylation regulates alternative splicing and cell migration in EGF signaling.40
280843292017SPSB1-mediated HnRNP A1 ubiquitylation regulates alternative splicing and cell migration in EGF signaling.40
260324132015SPSB1, a Novel Negative Regulator of the Transforming Growth Factor-β Signaling Pathway Targeting the Type II Receptor.17
260324132015SPSB1, a Novel Negative Regulator of the Transforming Growth Factor-β Signaling Pathway Targeting the Type II Receptor.17
247862062014SPSB1 promotes breast cancer recurrence by potentiating c-MET signaling.24
247862062014SPSB1 promotes breast cancer recurrence by potentiating c-MET signaling.24
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78

Citation

Dessen P

SPSB1 (splA/ryanodine receptor domain and SOCS box containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2015-03-01

Online version: http://atlasgeneticsoncology.org/gene/55096/haematological-explorer/teaching-explorer/meetings/