FNDC5 (fibronectin type III domain containing 5)

2015-03-01  

Identity

HGNC
FNDC5
LOCATION
1p35.1
LOCUSID
252995
ALIAS
FRCP2,irisin
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 252995
MIM: 611906
HGNC: 20240
Ensembl: ENSG00000160097

Variants:

dbSNP: 252995
ClinVar: 252995
TCGA: ENSG00000160097
COSMIC: FNDC5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160097ENST00000373471A0A0A0MRR6
ENSG00000160097ENST00000496770Q8NAU1
ENSG00000160097ENST00000649537A0A3B3ITP1

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
378157452024MiR-143-3p/FNDC5 axis: a novel regulator of insulin sensitivity.0
380435112024Relationship between Serum Irisin Level, All-Cause Mortality, and Cardiovascular Mortality in Peritoneal Dialysis Patients.1
381347422024Relationship of irisin with disease severity and dopamine uptake in Parkinson's disease patients.0
382183312024The role of irisin in kidney diseases.1
383091902024Role of irisin and myostatin on sarcopenia in malnourished patients diagnosed with GLIM criteria.2
383346692024The Role of FNDC5/Irisin in Cardiovascular Disease.3
384051552024The emerging roles of irisin in vascular calcification.1
385583032024FNDC5 inhibits malignant growth of human cervical cancer cells via restraining PI3K/AKT pathway.0
385914692024Irisin influences the in vitro differentiation of human mesenchymal stromal cells, promoting a tendency toward beiging adipogenesis.0
387880702024Plasma BDNF/Irisin Ratio Associates with Cognitive Function in Older People.0
388615372024Plasma irisin and the brain-derived neurotrophic factor levels in sedentary subjects: effect of 8-weeks lifestyle intervention.0
378157452024MiR-143-3p/FNDC5 axis: a novel regulator of insulin sensitivity.0
380435112024Relationship between Serum Irisin Level, All-Cause Mortality, and Cardiovascular Mortality in Peritoneal Dialysis Patients.1
381347422024Relationship of irisin with disease severity and dopamine uptake in Parkinson's disease patients.0
382183312024The role of irisin in kidney diseases.1

Citation

Dessen P

FNDC5 (fibronectin type III domain containing 5)

Atlas Genet Cytogenet Oncol Haematol. 2015-03-01

Online version: http://atlasgeneticsoncology.org/gene/55118