NPTX1 (neuronal pentraxin 1)

2015-05-01 Affiliation

Identity

HGNC

NPTX1

LOCATION

17q25.3

LOCUSID

4884

ALIAS

NP1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 4884
MIM: 602367
HGNC: 7952
Ensembl: ENSG00000171246

Variants:

dbSNP: 4884
ClinVar: 4884
TCGA: ENSG00000171246
COSMIC: NPTX1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000171246	ENST00000306773	Q15818

Expression (GTEx)

100

150

200

250

300

350

400

450

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
37515330	2023	Proteomic analysis of the human hippocampus identifies neuronal pentraxin 1 (NPTX1) as synapto-axonal target in late-stage Parkinson's disease.	0
37515330	2023	Proteomic analysis of the human hippocampus identifies neuronal pentraxin 1 (NPTX1) as synapto-axonal target in late-stage Parkinson's disease.	0
34788392	2022	NPTX1 mutations trigger endoplasmic reticulum stress and cause autosomal dominant cerebellar ataxia.	7
35216489	2022	Tryptophan Metabolites Regulate Neuropentraxin 1 Expression in Endothelial Cells.	1
34788392	2022	NPTX1 mutations trigger endoplasmic reticulum stress and cause autosomal dominant cerebellar ataxia.	7
35216489	2022	Tryptophan Metabolites Regulate Neuropentraxin 1 Expression in Endothelial Cells.	1
32255252	2021	Long non coding RNA SLC26A4-AS1 exerts antiangiogenic effects in human glioma by upregulating NPTX1 via NFKB1 transcriptional factor.	27
34212686	2021	Downregulation of NPTX1 induces cell cycle progression through Wnt/β-catenin signaling in breast cancer.	2
32255252	2021	Long non coding RNA SLC26A4-AS1 exerts antiangiogenic effects in human glioma by upregulating NPTX1 via NFKB1 transcriptional factor.	27
34212686	2021	Downregulation of NPTX1 induces cell cycle progression through Wnt/β-catenin signaling in breast cancer.	2
31118494	2020	MiR-4295 facilitates cell proliferation and metastasis in head and neck squamous cell carcinoma by targeting NPTX1.	11
31118494	2020	MiR-4295 facilitates cell proliferation and metastasis in head and neck squamous cell carcinoma by targeting NPTX1.	11
31113871	2019	As a downstream target of the AKT pathway, NPTX1 inhibits proliferation and promotes apoptosis in hepatocellular carcinoma.	10
31113871	2019	As a downstream target of the AKT pathway, NPTX1 inhibits proliferation and promotes apoptosis in hepatocellular carcinoma.	10
29345391	2018	NPTX1 inhibits colon cancer cell proliferation through down-regulating cyclin A2 and CDK2 expression.	23

Citation

Dessen P

NPTX1 (neuronal pentraxin 1)

Atlas Genet Cytogenet Oncol Haematol. 2015-05-01

Online version: http://atlasgeneticsoncology.org/gene/55213