PARN (poly(A)-specific ribonuclease)

2015-05-01  

Identity

HGNC
PARN
LOCATION
16p13.12
LOCUSID
5073
ALIAS
DAN,DKCB6,PFBMFT4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5073
MIM: 604212
HGNC: 8609
Ensembl: ENSG00000140694

Variants:

dbSNP: 5073
ClinVar: 5073
TCGA: ENSG00000140694
COSMIC: PARN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140694ENST00000341484O95453
ENSG00000140694ENST00000420015O95453
ENSG00000140694ENST00000437198O95453
ENSG00000140694ENST00000538472F5H1Z4
ENSG00000140694ENST00000539279O95453
ENSG00000140694ENST00000562896H3BT23
ENSG00000140694ENST00000563641H3BVG1
ENSG00000140694ENST00000569444H3BRK1
ENSG00000140694ENST00000650960A0A494C1N1
ENSG00000140694ENST00000650990A0A494C0W0
ENSG00000140694ENST00000651027A0A494C0P9
ENSG00000140694ENST00000651049A0A494C0Q2
ENSG00000140694ENST00000651300A0A494C008
ENSG00000140694ENST00000651348A0A494C002
ENSG00000140694ENST00000651634A0A494C1K5
ENSG00000140694ENST00000651760A0A494C0N0
ENSG00000140694ENST00000651865A0A494C0K5
ENSG00000140694ENST00000651913A0A494BZU6
ENSG00000140694ENST00000652051A0A494C156
ENSG00000140694ENST00000652066A0A494C1G3
ENSG00000140694ENST00000652501A0A494BZW7
ENSG00000140694ENST00000652541H3BVG1
ENSG00000140694ENST00000652727A0A494C0Q6

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
PERK regulates gene expressionREACTOMER-HSA-381042
ATF4 activates genesREACTOMER-HSA-380994
Gene ExpressionREACTOMER-HSA-74160
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
Deadenylation of mRNAREACTOMER-HSA-429947
Regulation of mRNA stability by proteins that bind AU-rich elementsREACTOMER-HSA-450531
KSRP (KHSRP) binds and destabilizes mRNAREACTOMER-HSA-450604

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
319365722020Translation Efficiency and Degradation of ER-Associated mRNAs Modulated by ER-Anchored poly(A)-Specific Ribonuclease (PARN).3
324570452020Regulation of poly(a)-specific ribonuclease activity by reversible lysine acetylation.5
319365722020Translation Efficiency and Degradation of ER-Associated mRNAs Modulated by ER-Anchored poly(A)-Specific Ribonuclease (PARN).3
324570452020Regulation of poly(a)-specific ribonuclease activity by reversible lysine acetylation.5
305915402019Poly(A)-specific ribonuclease sculpts the 3' ends of microRNAs.16
307702392019The RNase PARN Controls the Levels of Specific miRNAs that Contribute to p53 Regulation.41
309300562019Disruption of Telomerase RNA Maturation Kinetics Precipitates Disease.35
312739372019Impaired telomere integrity and rRNA biogenesis in PARN-deficient patients and knock-out models.18
313873002019The Intrinsically Disordered C-Terminal Domain Triggers Nucleolar Localization and Function Switch of PARN in Response to DNA Damage.7
314488432019From incomplete penetrance with normal telomere length to severe disease and telomere shortening in a family with monoallelic and biallelic PARN pathogenic variants.7
305915402019Poly(A)-specific ribonuclease sculpts the 3' ends of microRNAs.16
307702392019The RNase PARN Controls the Levels of Specific miRNAs that Contribute to p53 Regulation.41
309300562019Disruption of Telomerase RNA Maturation Kinetics Precipitates Disease.35
312739372019Impaired telomere integrity and rRNA biogenesis in PARN-deficient patients and knock-out models.18
313873002019The Intrinsically Disordered C-Terminal Domain Triggers Nucleolar Localization and Function Switch of PARN in Response to DNA Damage.7

Citation

Dessen P

PARN (poly(A)-specific ribonuclease)

Atlas Genet Cytogenet Oncol Haematol. 2015-05-01

Online version: http://atlasgeneticsoncology.org/gene/55216/parn-(poly(a)-specific-ribonuclease)