PARN (poly(A)-specific ribonuclease)

2015-05-01  

Identity

HGNC
LOCATION
16p13.12
LOCUSID
ALIAS
DAN,DKCB6,PFBMFT4
FUSION GENES

Other Information

Locus ID:

NCBI: 5073
MIM: 604212
HGNC: 8609
Ensembl: ENSG00000140694

Variants:

dbSNP: 5073
ClinVar: 5073
TCGA: ENSG00000140694
COSMIC: PARN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140694ENST00000341484O95453
ENSG00000140694ENST00000420015O95453
ENSG00000140694ENST00000437198O95453
ENSG00000140694ENST00000538472F5H1Z4
ENSG00000140694ENST00000539279O95453
ENSG00000140694ENST00000562896H3BT23
ENSG00000140694ENST00000563641H3BVG1
ENSG00000140694ENST00000569444H3BRK1
ENSG00000140694ENST00000650960A0A494C1N1
ENSG00000140694ENST00000650990A0A494C0W0
ENSG00000140694ENST00000651027A0A494C0P9
ENSG00000140694ENST00000651049A0A494C0Q2
ENSG00000140694ENST00000651300A0A494C008
ENSG00000140694ENST00000651348A0A494C002
ENSG00000140694ENST00000651634A0A494C1K5
ENSG00000140694ENST00000651760A0A494C0N0
ENSG00000140694ENST00000651865A0A494C0K5
ENSG00000140694ENST00000651913A0A494BZU6
ENSG00000140694ENST00000652051A0A494C156
ENSG00000140694ENST00000652066A0A494C1G3
ENSG00000140694ENST00000652501A0A494BZW7
ENSG00000140694ENST00000652541H3BVG1
ENSG00000140694ENST00000652727A0A494C0Q6

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
PERK regulates gene expressionREACTOMER-HSA-381042
ATF4 activates genesREACTOMER-HSA-380994
Gene ExpressionREACTOMER-HSA-74160
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
Deadenylation of mRNAREACTOMER-HSA-429947
Regulation of mRNA stability by proteins that bind AU-rich elementsREACTOMER-HSA-450531
KSRP (KHSRP) binds and destabilizes mRNAREACTOMER-HSA-450604

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
258487482015Exome sequencing links mutations in PARN and RTEL1 with familial pulmonary fibrosis and telomere shortening.135
127482832003Tristetraprolin and its family members can promote the cell-free deadenylation of AU-rich element-containing mRNAs by poly(A) ribonuclease.106
97366201998The deadenylating nuclease (DAN) is involved in poly(A) tail removal during the meiotic maturation of Xenopus oocytes.85
166012072006CUG-BP binds to RNA substrates and recruits PARN deadenylase.78
258935992015Poly(A)-specific ribonuclease deficiency impacts telomere biology and causes dyskeratosis congenita.72
264828782015Poly(A)-specific ribonuclease (PARN) mediates 3'-end maturation of the telomerase RNA component.68
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
106989482000Cap-dependent deadenylation of mRNA.58
227276652012Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex.56
108821332000Interaction between a poly(A)-specific ribonuclease and the 5' cap influences mRNA deadenylation rates in vitro.52

Citation

Dessen P

PARN (poly(A)-specific ribonuclease)

Atlas Genet Cytogenet Oncol Haematol. 2015-05-01

Online version: http://atlasgeneticsoncology.org/gene/55216/parn-(poly(a)-specific-ribonuclease)