SIX2 (SIX homeobox 2)

2015-05-01  

Identity

HGNC
SIX2
LOCATION
2p21
LOCUSID
10736
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10736
MIM: 604994
HGNC: 10888
Ensembl: ENSG00000170577

Variants:

dbSNP: 10736
ClinVar: 10736
TCGA: ENSG00000170577
COSMIC: SIX2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170577ENST00000303077Q9NPC8

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
374612282024NIK-mediated reactivation of SIX2 enhanced the CSC-like traits of hepatocellular carcinoma cells through suppressing ubiquitin-proteasome system.1
374612282024NIK-mediated reactivation of SIX2 enhanced the CSC-like traits of hepatocellular carcinoma cells through suppressing ubiquitin-proteasome system.1
359134142022De novo SIX2 activation in human kidneys treated with neonatal kidney stem/progenitor cells.5
359134142022De novo SIX2 activation in human kidneys treated with neonatal kidney stem/progenitor cells.5
332811912021Analysis of the mutational status of SIX1/2 and microRNA processing genes in paired primary and relapsed Wilms tumors and association with relapse.5
332811912021Analysis of the mutational status of SIX1/2 and microRNA processing genes in paired primary and relapsed Wilms tumors and association with relapse.5
324600302020SIX2 Regulates Human β Cell Differentiation from Stem Cells and Functional Maturation In Vitro.25
325068142020Maternal SLE and brachytelephalangic chondrodysplasia punctata in a patient with unrelated de novo RAF1 and SIX2 variants.0
333347852020Overexpression of Sine Oculis Homeobox Homolog 2 Predicts Poor Survival and Clinical Parameters of Patients with Colon Adenocarcinoma.0
324600302020SIX2 Regulates Human β Cell Differentiation from Stem Cells and Functional Maturation In Vitro.25
325068142020Maternal SLE and brachytelephalangic chondrodysplasia punctata in a patient with unrelated de novo RAF1 and SIX2 variants.0
333347852020Overexpression of Sine Oculis Homeobox Homolog 2 Predicts Poor Survival and Clinical Parameters of Patients with Colon Adenocarcinoma.0
306067202019SIX2 Mediates Late-Stage Metastasis via Direct Regulation of SOX2 and Induction of a Cancer Stem Cell Program.21
308947492019A NIK-SIX signalling axis controls inflammation by targeted silencing of non-canonical NF-κB.27
310904522019PPARG Negatively Modulates Six2 in Tumor Formation of Clear Cell Renal Cell Carcinoma.10

Citation

Dessen P

SIX2 (SIX homeobox 2)

Atlas Genet Cytogenet Oncol Haematol. 2015-05-01

Online version: http://atlasgeneticsoncology.org/gene/55221