ACP1 (acid phosphatase 1)

2003-11-01  

Identity

HGNC
LOCATION
2p25.3
LOCUSID
ALIAS
HAAP,LMW-PTP,LMWPTP

Other Information

Locus ID:

NCBI: 52
MIM: 171500
HGNC: 122
Ensembl: ENSG00000143727

Variants:

dbSNP: 52
ClinVar: 52
TCGA: ENSG00000143727
COSMIC: ACP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143727ENST00000272065P24666
ENSG00000143727ENST00000272067P24666
ENSG00000143727ENST00000405233F2Z2Q9
ENSG00000143727ENST00000405364F2Z2R9
ENSG00000143727ENST00000407983P24666
ENSG00000143727ENST00000407983A0A140VK37
ENSG00000143727ENST00000413140G5E9R5
ENSG00000143727ENST00000439645D3YTI2
ENSG00000143727ENST00000442386F2Z2R9
ENSG00000143727ENST00000453390F2Z2Q9

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Thiamine metabolismKEGGko00730
Riboflavin metabolismKEGGko00740
Adherens junctionKEGGko04520
Thiamine metabolismKEGGhsa00730
Riboflavin metabolismKEGGhsa00740
Adherens junctionKEGGhsa04520
Metabolic pathwaysKEGGhsa01100

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA445187OsteonecrosisDiseaseMultilinkAnnotationassociated25999454

References

Pubmed IDYearTitleCitations
346104712022Platelet-dependent signaling and Low Molecular Weight Protein Tyrosine Phosphatase expression promote aggressive phenotypic changes in gastrointestinal cancer cells.2
346104712022Platelet-dependent signaling and Low Molecular Weight Protein Tyrosine Phosphatase expression promote aggressive phenotypic changes in gastrointestinal cancer cells.2
330524342021Low molecular weight protein tyrosine phosphatase as signaling hub of cancer hallmarks.5
330524342021Low molecular weight protein tyrosine phosphatase as signaling hub of cancer hallmarks.5
320166962020LMWPTP modulates the antioxidant response and autophagy process in human chronic myeloid leukemia cells.5
322296872020Vemurafenib downmodulates aggressiveness mediators of colorectal cancer (CRC): Low Molecular Weight Protein Tyrosine Phosphatase (LMWPTP), Protein Tyrosine Phosphatase 1B (PTP1B) and Transforming Growth Factor β (TGFβ).3
320166962020LMWPTP modulates the antioxidant response and autophagy process in human chronic myeloid leukemia cells.5
322296872020Vemurafenib downmodulates aggressiveness mediators of colorectal cancer (CRC): Low Molecular Weight Protein Tyrosine Phosphatase (LMWPTP), Protein Tyrosine Phosphatase 1B (PTP1B) and Transforming Growth Factor β (TGFβ).3
303264762019Prediction of Time to Castration-Resistant Prostate Cancer Using Low-Molecular-Weight Protein Tyrosine Phosphatase Expression for Men with Metastatic Hormone-Naïve Prostate Cancer.2
303264762019Prediction of Time to Castration-Resistant Prostate Cancer Using Low-Molecular-Weight Protein Tyrosine Phosphatase Expression for Men with Metastatic Hormone-Naïve Prostate Cancer.2
295735682018Targeting LMW-PTP to sensitize melanoma cancer cells toward chemo- and radiotherapy.7
295735682018Targeting LMW-PTP to sensitize melanoma cancer cells toward chemo- and radiotherapy.7
286687162017Replication of rs300774, a genetic biomarker near ACP1, associated with suicide attempts in patients with schizophrenia: Relation to brain cholesterol biosynthesis.16
291874432017Total Knockdown of LMW-PTP in MDA-MB-231 Cells Reduces Osteoclastogenesis.1
286687162017Replication of rs300774, a genetic biomarker near ACP1, associated with suicide attempts in patients with schizophrenia: Relation to brain cholesterol biosynthesis.16

Citation

Dessen P

ACP1 (acid phosphatase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/553/gene-fusions-explorer/js/gene-explorer/